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Two Sigma Investments

Two Sigma Investments Portfolio holdings

AUM $124B
1-Year Est. Return 33.93%
This Fund
S&P 500
This Quarter Est. Return
+3.47%
1 Year Est. Return
+33.93%
3 Year Est. Return
+96.56%
5 Year Est. Return
+105.93%
10 Year Est. Return
+538.88%
AUM
$70.9B
AUM Growth
+$3.72B
Cap. Flow
+$541M
Cap. Flow %
0.76%
Top 10 Hldgs %
4.9%
Holding
4,545
New
899
Increased
1,598
Reduced
1,287
Closed
504

Sector Composition

Rank Sector Weight
1 Technology 15.53%
2 Financials 13%
3 Industrials 11.22%
4 Healthcare 10.29%
5 Consumer Discretionary 9.15%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake
Capital Flow
CTM icon
3801
Castellum
CTM
$58.3M
$68.1K ﹤0.01%
75,384
-2,181
-3% -$2.33K
KAPA
3802
Kairos Pharma
KAPA
$8.26M
$66.7K ﹤0.01%
94,008
+48,219
+105% +$45.1K
IPM
3803
Intelligent Protection Management Corp
IPM
$24.1M
$66.5K ﹤0.01%
+38,677
New +$73.8K
INAB icon
3804
IN8bio
INAB
$9.64M
$66K ﹤0.01%
28,214
-21,239
-43% -$40.4K
EPOW icon
3805
E-Power Inc
EPOW
$19M
$66K ﹤0.01%
+67,304
New +$76.4K
ALTG icon
3806
Alta Equipment Group
ALTG
$245M
$65.1K ﹤0.01%
14,148
-10,052
-42% -$55.2K
PALI icon
3807
Palisade Bio
PALI
$367M
$65K ﹤0.01%
+27,640
New +$53.1K
AQB icon
3808
AquaBounty Technologies
AQB
$6.02M
$64.9K ﹤0.01%
69,789
+32,224
+86% +$40.6K
CDXS icon
3809
Codexis
CDXS
$158M
$64.9K ﹤0.01%
39,804
+17,059
+75% +$34.8K
SERA icon
3810
Sera Prognostics
SERA
$81.1M
$64.8K ﹤0.01%
21,964
-9,772
-31% -$31.5K
CGTX icon
3811
Cognition Therapeutics
CGTX
$96.7M
$64.4K ﹤0.01%
47,729
-49,262
-51% -$80K
DARE icon
3812
Dare Bioscience
DARE
$21M
$63.8K ﹤0.01%
+33,036
New +$65.9K
ARAI
3813
Arrive AI Inc
ARAI
$13.8M
$63.7K ﹤0.01%
24,227
-5,000
-17% -$20.9K
SIGA icon
3814
SIGA Technologies
SIGA
$219M
$63.5K ﹤0.01%
+10,400
New +$74K
WEST icon
3815
Westrock Coffee
WEST
$803M
$63.1K ﹤0.01%
15,494
-500
-3% -$2.19K
KTTA icon
3816
Pasithea Therapeutics
KTTA
$16.9M
$62.9K ﹤0.01%
48,773
+13,013
+36% +$11.4K
BNGO icon
3817
Bionano Genomics
BNGO
$13.3M
$62K ﹤0.01%
+40,513
New +$70.1K
CNVS icon
3818
Cineverse
CNVS
$65.6M
$61.7K ﹤0.01%
29,245
-131,386
-82% -$356K
ORIO
3819
Orion Digital Corp
ORIO
$15.3M
$60.6K ﹤0.01%
56,633
-64,746
-53% -$92.1K
TCRT icon
3820
Alaunos Therapeutics
TCRT
$4.86M
$60K ﹤0.01%
+18,588
New +$60.1K
FGNX
3821
FG Nexus Inc
FGNX
$38.7M
$59.9K ﹤0.01%
+4,356
New +$76.4K
NMAD
3822
Nomad Power Solutions
NMAD
$65.8M
$59.6K ﹤0.01%
+15,174
New +$65.6K
LINK icon
3823
Interlink Electronics
LINK
$80.3M
$59.1K ﹤0.01%
+15,242
New +$78.9K
AUID icon
3824
authID Inc
AUID
$10.6M
$58.7K ﹤0.01%
+67,076
New +$127K
DWSN icon
3825
Dawson Geophysical
DWSN
$135M
$58.4K ﹤0.01%
37,416
+7,991
+27% +$15.1K

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Two Sigma Investments's Q4 2025 Portfolio in Review

As of Q4 2025, Two Sigma Investments held 4,545 positions worth $70.9B, up 5.5% from $67.2B the previous quarter. Its ten largest holdings account for 4.9% of the portfolio.

Two Sigma Investments's Q4 2025 filing shows 899 new, 1,598 increased, 1,287 reduced and 504 closed positions. Its largest new stake was Vanguard Real Estate ETF: 3,573,400 shares worth $316M. The largest sale was State Street Financial Select Sector SPDR ETF, an estimated $547M.

By sector, the portfolio is most concentrated in Technology at 16% of assets, down from 16% a quarter earlier, followed by Financials and Industrials.

  • Two Sigma Investments's largest Q4 2025 buy was Vanguard Real Estate ETF: 3,573,400 shares worth $316M.
  • Two Sigma Investments added most to State Street Technology Select Sector SPDR ETF in Q4 2025, an estimated $395M increase.
  • Two Sigma Investments's biggest Q4 2025 reduction was State Street Financial Select Sector SPDR ETF, cutting an estimated $547M.
  • Two Sigma Investments fully exited State Street SPDR Dow Jones Industrial Average ETF Trust in Q4 2025, selling an estimated $240M.
  • Two Sigma Investments's ten largest holdings make up 4.9% of its $70.9B portfolio in Q4 2025.
  • Two Sigma Investments opened 899 new positions and closed 504 in Q4 2025.
  • Two Sigma Investments's portfolio value rose 5.5% quarter-over-quarter to $70.9B.

Based on Two Sigma Investments's 13F filing for Q4 2025, filed 17 Feb 2026.