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Two Sigma Investments

Two Sigma Investments Portfolio holdings

AUM $124B
1-Year Est. Return 33.93%
This Fund
S&P 500
This Quarter Est. Return
-3.07%
1 Year Est. Return
+33.93%
3 Year Est. Return
+96.56%
5 Year Est. Return
+105.93%
10 Year Est. Return
+538.88%
AUM
$46.8B
AUM Growth
+$933M
Cap. Flow
+$2.08B
Cap. Flow %
4.45%
Top 10 Hldgs %
8.13%
Holding
3,617
New
458
Increased
1,225
Reduced
1,321
Closed
453

Top Sells

Rank Stock Value
1
LLY icon
Eli Lilly
LLY
+$255M
2
PGR icon
Progressive
PGR
+$244M
3
V icon
Visa
V
+$238M
4
LRCX icon
Lam Research
LRCX
+$201M
5
ELV icon
Elevance Health
ELV
+$190M

Sector Composition

Rank Sector Weight
1 Technology 17.88%
2 Healthcare 13.28%
3 Financials 10.31%
4 Industrials 9.8%
5 Consumer Discretionary 8.58%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake
Capital Flow
ABUS icon
2951
Arbutus Biopharma
ABUS
$915M
$63.8K ﹤0.01%
18,286
-11,200
-38% -$37.4K
ADCT icon
2952
ADC Therapeutics
ADCT
$144M
$63K ﹤0.01%
44,686
-138,545
-76% -$235K
CELU icon
2953
Celularity
CELU
$20.3M
$62.9K ﹤0.01%
36,380
-8,534
-19% -$16.2K
FSI icon
2954
Flexible Solutions
FSI
$64.1M
$62.7K ﹤0.01%
+12,424
New +$68.4K
ARAY icon
2955
Accuray
ARAY
$34M
$62.7K ﹤0.01%
35,028
-37,453
-52% -$78.4K
TPIC
2956
DELISTED
TPI Composites
TPIC
$62.5K ﹤0.01%
+77,521
New +$101K
STRO icon
2957
Sutro Biopharma
STRO
$421M
$62.4K ﹤0.01%
9,588
-22,041
-70% -$347K
NRXP icon
2958
NRX Pharmaceuticals
NRXP
$153M
$61.8K ﹤0.01%
+30,146
New +$84.9K
VERI icon
2959
Veritone
VERI
$122M
$61.1K ﹤0.01%
+26,260
New +$76.2K
XLO icon
2960
Xilio Therapeutics
XLO
$60.3M
$60.9K ﹤0.01%
6,005
+5,232
+677% +$65.8K
GGRP
2961
Glimpse Group
GGRP
$18.7M
$57.4K ﹤0.01%
+49,461
New +$81.2K
BIOA
2962
BioAge Labs
BIOA
$538M
$56.9K ﹤0.01%
+15,145
New +$70K
BGFV
2963
DELISTED
Big 5 Sporting Goods
BGFV
$56.6K ﹤0.01%
58,569
-75,290
-56% -$103K
HOWL icon
2964
Werewolf Therapeutics
HOWL
$19.3M
$56.5K ﹤0.01%
58,132
-35,308
-38% -$46.2K
ANRO icon
2965
Alto Neuroscience
ANRO
$1.11B
$56.5K ﹤0.01%
26,142
-4,558
-15% -$16.3K
BPT
2966
DELISTED
BP Prudhoe Bay Royalty Trust
BPT
$55.6K ﹤0.01%
100,497
-502
-0.5% -$284
QNCX icon
2967
Quince Therapeutics
QNCX
$29.5M
$54.7K ﹤0.01%
206
+54
+36% +$16.5K
GETY icon
2968
Getty Images
GETY
$183M
$54.7K ﹤0.01%
+31,599
New +$75.2K
IMRX icon
2969
Immuneering
IMRX
$292M
$54.4K ﹤0.01%
35,757
-14,800
-29% -$26.9K
IBIO icon
2970
iBio
IBIO
$70M
$54.2K ﹤0.01%
+13,484
New +$52.4K
RR icon
2971
Richtech Robotics
RR
$360M
$53.2K ﹤0.01%
26,886
-15,117
-36% -$37.2K
SQNS
2972
Sequans Communications SA
SQNS
$41.3M
$52.5K ﹤0.01%
2,499
-3,381
-58% -$92.3K
SLS icon
2973
SELLAS Life Sciences
SLS
$2.36B
$52.1K ﹤0.01%
+48,287
New +$57.3K
BCG
2974
Binah Capital Group
BCG
$22.7M
$51.9K ﹤0.01%
26,871
REAX icon
2975
Real Brokerage
REAX
$466M
$51.5K ﹤0.01%
12,696
-27,930
-69% -$133K

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Two Sigma Investments's Q1 2025 Portfolio in Review

As of Q1 2025, Two Sigma Investments held 3,617 positions worth $46.8B, up 2% from $45.9B the previous quarter. Its ten largest holdings account for 8.1% of the portfolio.

Two Sigma Investments deployed $2.08B of net new capital in Q1 2025, opening 458 new positions and adding to 1,225 existing holdings. Its largest new stake was Advanced Micro Devices: 2,246,952 shares worth $231M.

By sector, the portfolio is most concentrated in Technology at 18% of assets, up from 16% a quarter earlier, followed by Healthcare and Financials.

On the sell side, the largest reduction was Eli Lilly, an estimated $255M trimmed.

  • Two Sigma Investments's largest Q1 2025 buy was Advanced Micro Devices: 2,246,952 shares worth $231M.
  • Two Sigma Investments added most to State Street SPDR S&P 500 ETF Trust in Q1 2025, an estimated $510M increase.
  • Two Sigma Investments's biggest Q1 2025 reduction was Eli Lilly, cutting an estimated $255M.
  • Two Sigma Investments fully exited Coinbase in Q1 2025, selling an estimated $45M.
  • Two Sigma Investments's ten largest holdings make up 8.1% of its $46.8B portfolio in Q1 2025.
  • Two Sigma Investments opened 458 new positions and closed 453 in Q1 2025.
  • Two Sigma Investments's portfolio value rose 2% quarter-over-quarter to $46.8B.

Based on Two Sigma Investments's 13F filing for Q1 2025, filed 15 May 2025.