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Two Sigma Advisers

Two Sigma Advisers Portfolio holdings

AUM $51.4B
1-Year Est. Return 31.07%
This Fund
S&P 500
This Quarter Est. Return
-3%
1 Year Est. Return
+31.07%
3 Year Est. Return
+128.94%
5 Year Est. Return
+161.75%
10 Year Est. Return
+607.04%
AUM
$44.4B
AUM Growth
+$1.2B
Cap. Flow
+$3.32B
Cap. Flow %
7.48%
Top 10 Hldgs %
17.65%
Holding
2,641
New
312
Increased
1,037
Reduced
994
Closed
281

Top Buys

Rank Stock Value
1
AVGO icon
Broadcom
AVGO
+$519M
2
CRM icon
Salesforce
CRM
+$460M
3
REGN icon
Regeneron Pharmaceuticals
REGN
+$381M
4
BSX icon
Boston Scientific
BSX
+$347M
5
ISRG icon
Intuitive Surgical
ISRG
+$319M

Top Sells

Rank Stock Value
1
V icon
Visa
V
+$555M
2
LLY icon
Eli Lilly
LLY
+$536M
3
META icon
Meta Platforms (Facebook)
META
+$433M
4
PGR icon
Progressive
PGR
+$330M
5
LRCX icon
Lam Research
LRCX
+$294M

Sector Composition

Rank Sector Weight
1 Technology 25.86%
2 Healthcare 15.38%
3 Financials 14.3%
4 Consumer Discretionary 11.43%
5 Industrials 10.56%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RPAY icon
2226
Repay Holdings
RPAY
$338M
$115K ﹤0.01%
20,600
-41,800
-67% -$288K
ZURA icon
2227
Zura Bio
ZURA
$513M
$112K ﹤0.01%
86,900
+74,100
+579% +$117K
AEVA
2228
Aeva Technologies
AEVA
$981M
$112K ﹤0.01%
15,960
-32,740
-67% -$135K
KLTR icon
2229
Kaltura
KLTR
$212M
$111K ﹤0.01%
+58,800
New +$131K
BVS icon
2230
Bioventus
BVS
$904M
$110K ﹤0.01%
12,032
-400
-3% -$4K
KMDA icon
2231
Kamada
KMDA
$413M
$110K ﹤0.01%
+16,632
New +$118K
PRME icon
2232
Prime Medicine
PRME
$551M
$107K ﹤0.01%
53,900
+10,700
+25% +$27.3K
PACK icon
2233
Ranpak Holdings
PACK
$506M
$107K ﹤0.01%
19,700
-76,700
-80% -$504K
ASUR icon
2234
Asure Software
ASUR
$243M
$106K ﹤0.01%
11,100
-2,400
-18% -$26.3K
LOGC
2235
DELISTED
ContextLogic
LOGC
$106K ﹤0.01%
15,156
-100
-0.7% -$745
INFU icon
2236
InfuSystem Holdings
INFU
$199M
$105K ﹤0.01%
19,500
+7,300
+60% +$53.4K
CLNE icon
2237
Clean Energy Fuels
CLNE
$414M
$105K ﹤0.01%
67,500
-110,800
-62% -$282K
GEVO icon
2238
Gevo
GEVO
$353M
$105K ﹤0.01%
90,100
-31,800
-26% -$53.3K
IGMS
2239
DELISTED
IGM Biosciences
IGMS
$104K ﹤0.01%
+90,500
New +$168K
DAWN
2240
DELISTED
Day One Biopharmaceuticals
DAWN
$102K ﹤0.01%
12,800
-93,800
-88% -$1.01M
LCTX icon
2241
Lineage Cell Therapeutics
LCTX
$259M
$101K ﹤0.01%
223,364
+136,400
+157% +$80K
DOUG icon
2242
Douglas Elliman
DOUG
$157M
$101K ﹤0.01%
58,515
-22,900
-28% -$41.4K
INTT icon
2243
inTEST
INTT
$151M
$99.3K ﹤0.01%
14,200
-41,700
-75% -$346K
CMTL icon
2244
Comtech Telecommunications
CMTL
$50.3M
$99.1K ﹤0.01%
61,936
-123,063
-67% -$282K
PRTS icon
2245
CarParts.com
PRTS
$43.2M
$98.8K ﹤0.01%
9,880
-13,930
-59% -$153K
API
2246
Agora
API
$334M
$97.3K ﹤0.01%
+24,200
New +$126K
QSI icon
2247
Quantum-Si Incorporated
QSI
$163M
$94.7K ﹤0.01%
+78,900
New +$151K
UDMY
2248
DELISTED
Udemy
UDMY
$94.7K ﹤0.01%
+12,200
New +$104K
AHRT
2249
AH Realty Trust
AHRT
$540M
$94.6K ﹤0.01%
12,600
-80,500
-86% -$731K
OPI
2250
DELISTED
Office Properties Income Trust
OPI
$93.2K ﹤0.01%
204,427
-89,700
-30% -$76.6K
88 89
90
91 92

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Two Sigma Advisers's Q1 2025 Portfolio in Review

As of Q1 2025, Two Sigma Advisers held 2,641 positions worth $44.4B, up 2.8% from $43.2B the previous quarter. Its ten largest holdings account for 18% of the portfolio.

Two Sigma Advisers deployed $3.32B of net new capital in Q1 2025, opening 312 new positions and adding to 1,037 existing holdings. Its largest new stake was Regeneron Pharmaceuticals: 553,800 shares worth $351M.

By sector, the portfolio is most concentrated in Technology at 26% of assets, up from 25% a quarter earlier, followed by Healthcare and Financials.

On the sell side, the largest reduction was Visa, an estimated $555M trimmed.

  • Two Sigma Advisers's largest Q1 2025 buy was Regeneron Pharmaceuticals: 553,800 shares worth $351M.
  • Two Sigma Advisers added most to Broadcom in Q1 2025, an estimated $519M increase.
  • Two Sigma Advisers's biggest Q1 2025 reduction was Visa, cutting an estimated $555M.
  • Two Sigma Advisers fully exited Abbott in Q1 2025, selling an estimated $158M.
  • Two Sigma Advisers's ten largest holdings make up 18% of its $44.4B portfolio in Q1 2025.
  • Two Sigma Advisers opened 312 new positions and closed 281 in Q1 2025.
  • Two Sigma Advisers's portfolio value rose 2.8% quarter-over-quarter to $44.4B.

Based on Two Sigma Advisers's 13F filing for Q1 2025, filed 15 May 2025.