TCM

Tekla Capital Management Portfolio holdings

AUM $2.56B

2023 Q2 2023 Q1 2022 Q4 2022 Q3 2022 Q2 2022 Q1 2021 Q4 2021 Q3 2021 Q2 2021 Q1 2020 Q4 2020 Q3 2020 Q2 2020 Q1 2019 Q4 2019 Q3 2019 Q2 2019 Q1 2018 Q4 2018 Q3 2018 Q2 2018 Q1 2017 Q4 2017 Q3 2017 Q2 2017 Q1 2016 Q4 2016 Q3 2016 Q2 2016 Q1 2015 Q4 2015 Q3 2015 Q2 2015 Q1 2014 Q4 2014 Q3 2014 Q2 2014 Q1 2013 Q4 2013 Q3 2013 Q2

This Quarter Return

-0.34%

1 Year Return

+18.15%

3 Year Return

+62.34%

5 Year Return

+140.22%

10 Year Return

+499.57%

AUM

$2.63B

AUM Growth

-$21.2M (-0.8%)

Cap. Flow

+$36.2M

Cap. Flow % of AUM

1.38%

Top 10 Holdings % Top 10 Hldgs %

39.68%

Holding

190

New

Increased

Reduced

Closed

Top Buys

1	Elevance Health ELV	$45.7M
2	SGEN Seagen Inc. Common Stock SGEN	$22.8M
3	Sarepta Therapeutics SRPT	$19.9M
4	Regeneron Pharmaceuticals REGN	$18.2M
5	Exelixis EXEL	$14.1M

Top Sells

1	HZNP Horizon Therapeutics Public Limited Company Ordinary Shares HZNP	$47.2M
2	Stryker SYK	$26.4M
3	Zimmer Biomet ZBH	$24.7M
4	Lantheus LNTH	$21.7M
5	Humana HUM	$19.9M

Sector Composition

1	Healthcare	96.54%
2	Real Estate	2.01%
3	Industrials	0.2%

Communication Services

Advertising Agencies

Broadcasting

Electronic Gaming & Multimedia

Entertainment

Internet Content & Information

Publishing

Telecom Services

Consumer Discretionary

Apparel Manufacturing

Apparel Retail

Auto Manufacturers

Auto Parts

Auto & Truck Dealerships

Department Stores

Footwear & Accessories

Furnishings, Fixtures & Appliances

Gambling

Home Improvement Retail

Internet Retail

Leisure

Lodging

Luxury Goods

Packaging & Containers

Personal Services

Recreational Vehicles

Residential Construction

Resorts & Casinos

Restaurants

Specialty Retail

Textile Manufacturing

Travel Services

Consumer Staples

Beverages - Brewers

Beverages - Non-Alcoholic

Beverages - Wineries & Distilleries

Confectioners

Discount Stores

Education & Training Services

Farm Products

Food Distribution

Grocery Stores

Household & Personal Products

Packaged Foods

Tobacco

Energy

Oil & Gas Drilling

Oil & Gas Equipment & Services

Oil & Gas Exploration & Production

Oil & Gas Integrated

Oil & Gas Midstream

Oil & Gas Refining & Marketing

Thermal Coal

Uranium

Financials

Asset Management

Banks - Diversified

Banks - Regional

Capital Markets

Credit Services

Diversified Insurance

Financial Conglomerates

Financial Data & Stock Exchanges

Insurance Brokers

Life Insurance

Mortgage Finance

Property & Casualty Insurance

Reinsurance

Shell Companies

Specialty - Insurance

Healthcare

Biotechnology

Diagnostics & Research

Drug Manufacturers - General

Drug Manufacturers - Specialty & Generic

Healthcare Plans

Health Information Services

Medical Care Facilities

Medical Devices

Medical Distribution

Medical Instruments & Supplies

Pharmaceutical Retailers

Industrials

Aerospace & Defense

Airlines

Airports & Air Services

Building Products & Equipment

Business Equipment & Supplies

Conglomerates

Consulting Services

Electrical Equipment & Parts

Engineering & Construction

Farm & Heavy Construction Machinery

Industrial Distribution

Infrastructure Operations

Integrated Freight & Logistics

Marine Shipping

Metal Fabrication

Pollution & Treatment Controls

Railroads

Rental & Leasing Services

Security & Protection Services

Specialty Business Services

Specialty Industrial Machinery

Staffing & Employment Services

Tools & Accessories

Trucking

Waste Management

Materials

Agricultural Inputs

Aluminum

Building Materials

Chemicals

Coking Coal

Copper

Gold

Lumber & Wood Production

Other Industrial Metals & Mining

Other Precious Metals & Mining

Paper & Paper Products

Silver

Specialty Chemicals

Steel

Real Estate

Diversified REIT

Healthcare Facilities REIT

Hotel & Motel REIT

Industrial REIT

Mortgage REIT

Office REIT

Real Estate Development

Real Estate Diversified

Real Estate Services

Residential REIT

Retail REIT

Specialty REIT

Technology

Communication Equipment

Computer Hardware

Consumer Electronics

Electronic Components

Electronics & Computer Distribution

Information Technology Services

Scientific & Technical Instruments

Semiconductor Equipment & Materials

Semiconductors

Software - Application

Software - Infrastructure

Solar

Utilities

Diversified Utilities

Electric Utilities

Gas Utilities

Independent Power Producers

Renewable Electricity

Water Utilities

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
101	101 Welltower WELL $112B	$2.97M	0.11%	41,484	–	–
102	102 Ventas VTR $30.7B	$2.89M	0.11%	66,681	–	–
103	103 Pyxis Oncology PYXS $91.2M	$2.84M	0.11%	708,303	–	–
104	104 LivaNova LIVN $3.09B	$2.78M	0.11%	+63,880	New	+$2.78M
105	105 Natera NTRA $23B	$2.74M	0.1%	49,272	–	–
106	106 Baxter International BAX $12.1B	$2.73M	0.1%	+67,312	New	+$2.73M
107	107 Ultragenyx Pharmaceutical RARE $3.04B	$2.69M	0.1%	67,065	–	–
108	108 Assertio ASRT $78M	$2.62M	0.1%	410,575	–	–
109	109 Ardelyx ARDX $1.57B	$2.58M	0.1%	539,408	–	–
110	110 Arrowhead Research ARWR $3.84B	$2.55M	0.1%	100,422	–	–
111	111 BridgeBio Pharma BBIO $9.91B	$2.5M	0.1%	+150,921	New	+$2.5M
112	112 CRISPR Therapeutics CRSP $4.82B	$2.49M	0.09%	55,080	–	–
113	113 Syndax Pharmaceuticals SNDX $1.39B	$2.49M	0.09%	117,717	–	–
114	MRTX 114 DELISTED Mirati Therapeutics, Inc. Common Stock MRTX	$2.43M	0.09%	65,490	–	–
115	115 Align Technology ALGN $9.59B	$2.31M	0.09%	6,925 -43,899	-86%	-$14.7M
116	GRTX 116 DELISTED Galera Therapeutics, Inc. Common Stock GRTX	$2.3M	0.09%	898,374	–	–
117	117 Option Care Health OPCH $4.7B	$2.06M	0.08%	64,975	–	–
118	118 Philips PHG $25.8B	$2.02M	0.08%	123,709	–	–
119	119 Icon ICLR $14B	$1.99M	0.08%	9,334	–	–
120	KDNY 120 DELISTED Chinook Therapeutics, Inc. Common Stock KDNY	$1.93M	0.07%	+83,500	New	+$1.93M
121	BCYC 121 Bicycle Therapeutics BCYC $492M	$1.89M	0.07%	88,676	–	–
122	122 Perrigo PRGO $3.21B	$1.84M	0.07%	51,224	–	–
123	123 Immunovant IMVT $2.91B	$1.79M	0.07%	+115,400	New	+$1.79M
124	124 Medpace MEDP $13.5B	$1.77M	0.07%	9,435	–	–
125	125 Takeda Pharmaceutical TAK $47.8B	$1.73M	0.07%	105,073	–	–