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Stempoint Capital Portfolio holdings

AUM $522M
1-Year Est. Return 281.95%
This Fund
S&P 500
This Quarter Est. Return
+54.5%
1 Year Est. Return
+281.95%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$583M
AUM Growth
+$84.1M
Cap. Flow
-$23.8M
Cap. Flow %
-4.08%
Top 10 Hldgs %
45.64%
Holding
119
New
32
Increased
28
Reduced
17
Closed
42

Top Buys

Rank Stock Value
1
ACLX
Arcellx
ACLX
+$25.6M
2
ABVX
Abivax
ABVX
+$24.6M
3
TWST icon
Twist Bioscience
TWST
+$16.2M
4
CNTA
Centessa Pharmaceuticals
CNTA
+$12.6M
5
ADPT icon
Adaptive Biotechnologies
ADPT
+$9.9M

Top Sells

Rank Stock Value
1
ROIV icon
Roivant Sciences
ROIV
+$63.7M
2
DNLI icon
Denali Therapeutics
DNLI
+$22.2M
3
IMVT icon
Immunovant
IMVT
+$21.1M
4
QURE icon
uniQure
QURE
+$18.5M
5
WVE icon
Wave Life Sciences
WVE
+$15.4M

Sector Composition

Rank Sector Weight
1 Healthcare 99.91%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
JAZZ icon
101
Jazz Pharmaceuticals
JAZZ
$15.5B
– –
-39,072
Closed -$5.15M
KALV
102
DELISTED
KalVista Pharmaceuticals
KALV
– –
-56,770
Closed -$691K
DFTX
103
Definium Therapeutics
DFTX
$5.88B
– –
-76,875
Closed -$906K
ORIC icon
104
Oric Pharmaceuticals
ORIC
$1.11B
– –
-166,461
Closed -$2M
PEPG icon
105
PepGen
PEPG
$156M
– –
-389,189
Closed -$1.8M
PYXS icon
106
Pyxis Oncology
PYXS
$150M
– –
-689,538
Closed -$1.53M
QQQ icon
107
Invesco QQQ Trust
QQQ
$466B
– –
-3,797
Closed -$2.28M
RNAM
108
DELISTED
Avidity Biosciences
RNAM
– –
-114,053
Closed -$4.97M
RZLT icon
109
Rezolute
RZLT
$444M
– –
-917,630
Closed -$8.63M
SNDX icon
110
CALL
Syndax Pharmaceuticals
SNDX
$2.02B
– –
-100,000
Closed -$55K
TARA icon
111
Protara Therapeutics
TARA
$230M
– –
-363,666
Closed -$1.58M
TNGX icon
112
Tango Therapeutics
TNGX
$4.65B
– –
-245,378
Closed -$2.06M
UTHR icon
113
United Therapeutics
UTHR
$22.7B
– –
-6,264
Closed -$2.63M
VTYX
114
DELISTED
Ventyx Biosciences
VTYX
– –
-167,470
Closed -$521K
WVE icon
115
Wave Life Sciences
WVE
$1.12B
– –
-2,110,152
Closed -$15.4M
XBI icon
116
PUT
State Street SPDR S&P Biotech ETF
XBI
$10.4B
– –
-1,490,100
Closed -$725K
PCSC
117
Perceptive Capital Solutions
PCSC
$123M
– –
-150,000
Closed -$1.59M
TECX
118
Tectonic Therapeutic
TECX
$615M
– –
-188,999
Closed -$2.97M
ZBIO
119
Zenas BioPharma
ZBIO
$1.86B
– –
-38,742
Closed -$860K
1 2 3 4
5

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Stempoint Capital's Q4 2025 Portfolio in Review

As of Q4 2025, Stempoint Capital held 119 positions worth $583M, up 17% from $499M the previous quarter. Its ten largest holdings account for 46% of the portfolio.

Stempoint Capital withdrew a net $23.8M in Q4 2025, closing 42 positions and reducing 17 holdings. Its most notable exit was Wave Life Sciences, an estimated $15.4M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 99% a quarter earlier, followed by Financials.

Against the trend, Stempoint Capital opened a new position in Twist Bioscience worth $16.4M.

  • Stempoint Capital's largest Q4 2025 buy was Twist Bioscience: 518,355 shares worth $16.4M.
  • Stempoint Capital added most to Arcellx in Q4 2025, an estimated $25.6M increase.
  • Stempoint Capital's biggest Q4 2025 reduction was Roivant Sciences, cutting an estimated $63.7M.
  • Stempoint Capital fully exited Wave Life Sciences in Q4 2025, selling an estimated $15.4M.
  • Stempoint Capital's ten largest holdings make up 46% of its $583M portfolio in Q4 2025.
  • Stempoint Capital opened 32 new positions and closed 42 in Q4 2025.
  • Stempoint Capital's portfolio value rose 17% quarter-over-quarter to $583M.

Based on Stempoint Capital's 13F filing for Q4 2025, filed 17 Feb 2026.