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Soleus Capital Management Portfolio holdings

AUM $2.47B
1-Year Est. Return 115.63%
This Fund
S&P 500
This Quarter Est. Return
+32.58%
1 Year Est. Return
+115.63%
3 Year Est. Return
+435.52%
5 Year Est. Return
+604.31%
10 Year Est. Return
–
AUM
$1.99B
AUM Growth
+$476M
Cap. Flow
+$118M
Cap. Flow %
5.96%
Top 10 Hldgs %
48.1%
Holding
113
New
18
Increased
27
Reduced
34
Closed
25

Top Buys

Rank Stock Value
1
INSP icon
Inspire Medical Systems
INSP
+$62.7M
2
ELV icon
Elevance Health
ELV
+$59M
3
TGTX icon
TG Therapeutics
TGTX
+$52.7M
4
TWST icon
Twist Bioscience
TWST
+$45.8M
5
NVCR icon
NovoCure
NVCR
+$36.6M

Top Sells

Rank Stock Value
1
CELC icon
Celcuity
CELC
+$73.4M
2
STAA icon
STAAR Surgical
STAA
+$59.2M
3
ALNY icon
Alnylam Pharmaceuticals
ALNY
+$37.3M
4
GRFS
Grifois
GRFS
+$32.5M
5
URGN icon
UroGen Pharma
URGN
+$27M

Sector Composition

Rank Sector Weight
1 Healthcare 94.2%
2 Consumer Staples 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MURA
101
DELISTED
Mural Oncology
MURA
– –
-1,323,877
Closed -$3.27M
OFIX icon
102
Orthofix Medical
OFIX
$432M
– –
-261,147
Closed -$2.91M
RVMD icon
103
Revolution Medicines
RVMD
$42.4B
– –
-10,000
Closed -$368K
SKIN icon
104
SkinHealth Systems
SKIN
$99.5M
– –
-1,000,000
Closed -$1.91M
SLNO
105
DELISTED
Soleno Therapeutics
SLNO
– –
-10,000
Closed -$838K
SRDX
106
DELISTED
Surmodics
SRDX
– –
-789,060
Closed -$23.4M
SRRK icon
107
Scholar Rock
SRRK
$6.41B
– –
-125,000
Closed -$4.43M
THTX
108
DELISTED
Theratechnologies
THTX
– –
-4,801,376
Closed -$11.3M
TNDM icon
109
Tandem Diabetes Care
TNDM
$1.29B
– –
-200,000
Closed -$3.73M
UNH icon
110
UnitedHealth
UNH
$367B
– –
-86,250
Closed -$26.9M
WGS icon
111
GeneDx Holdings
WGS
$2.08B
– –
-40,000
Closed -$3.69M
XENE icon
112
Xenon Pharmaceuticals
XENE
$6.24B
– –
-78,800
Closed -$2.47M
YMAB
113
DELISTED
Y-mAbs Therapeutics
YMAB
– –
-349,982
Closed -$1.58M
1 2 3 4
5

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Soleus Capital Management's Q3 2025 Portfolio in Review

As of Q3 2025, Soleus Capital Management held 113 positions worth $1.99B, up 32% from $1.51B the previous quarter. Its ten largest holdings account for 48% of the portfolio.

Soleus Capital Management deployed $118M of net new capital in Q3 2025, opening 18 new positions and adding to 27 existing holdings. Its largest new stake was Amicus Therapeutics: 4,690,000 shares worth $37M.

By sector, the portfolio is most concentrated in Healthcare at 94% of assets, down from 96% a quarter earlier, followed by Consumer Staples.

On the sell side, the largest reduction was Celcuity, an estimated $73.4M trimmed.

  • Soleus Capital Management's largest Q3 2025 buy was Amicus Therapeutics: 4,690,000 shares worth $37M.
  • Soleus Capital Management added most to Inspire Medical Systems in Q3 2025, an estimated $62.7M increase.
  • Soleus Capital Management's biggest Q3 2025 reduction was Celcuity, cutting an estimated $73.4M.
  • Soleus Capital Management fully exited UnitedHealth in Q3 2025, selling an estimated $26.9M.
  • Soleus Capital Management's ten largest holdings make up 48% of its $1.99B portfolio in Q3 2025.
  • Soleus Capital Management opened 18 new positions and closed 25 in Q3 2025.
  • Soleus Capital Management's portfolio value rose 32% quarter-over-quarter to $1.99B.

Based on Soleus Capital Management's 13F filing for Q3 2025, filed 14 Nov 2025.