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Silverarc Capital Management Portfolio holdings

AUM $980M
1-Year Est. Return 470.8%
This Fund
S&P 500
This Quarter Est. Return
+59.01%
1 Year Est. Return
+470.8%
3 Year Est. Return
+3,352.06%
5 Year Est. Return
+7,957.7%
10 Year Est. Return
–
AUM
$720M
AUM Growth
-$21.6M
Cap. Flow
-$169M
Cap. Flow %
-23.52%
Top 10 Hldgs %
49.7%
Holding
103
New
21
Increased
18
Reduced
27
Closed
35

Top Buys

Rank Stock Value
1
CELC icon
Celcuity
CELC
+$23.5M
2
IMNM icon
Immunome
IMNM
+$19.8M
3
KALV
KalVista Pharmaceuticals
KALV
+$14.1M
4
COGT icon
Cogent Biosciences
COGT
+$12.1M
5
PFE icon
Pfizer
PFE
+$10.6M

Top Sells

Rank Stock Value
1
RNAM
Avidity Biosciences
RNAM
+$36.8M
2
AKRO
Akero Therapeutics
AKRO
+$30.6M
3
RYTM icon
Rhythm Pharmaceuticals
RYTM
+$24.8M
4
INSM icon
Insmed
INSM
+$24.7M
5
CDTX
Cidara Therapeutics
CDTX
+$21.2M

Sector Composition

Rank Sector Weight
1 Healthcare 95.99%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BCAX
101
Bicara Therapeutics
BCAX
$1.73B
– –
-250,606
Closed -$3.96M
MBX
102
MBX Biosciences
MBX
$3.16B
– –
-15,000
Closed -$263K
LBRX
103
LB Pharmaceuticals
LBRX
$1.17B
– –
-70,000
Closed -$1.11M
1 2 3 4
5

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MFWP
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FCM
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KL
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Silverarc Capital Management's Q4 2025 Portfolio in Review

As of Q4 2025, Silverarc Capital Management held 103 positions worth $720M, down 2.9% from $742M the previous quarter. Its ten largest holdings account for 50% of the portfolio.

Silverarc Capital Management withdrew a net $169M in Q4 2025, closing 35 positions and reducing 27 holdings. Its most notable exit was Avidity Biosciences, an estimated $36.8M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 96% of assets, up from 93% a quarter earlier.

Against the trend, Silverarc Capital Management opened a new position in Immunome worth $24.2M.

  • Silverarc Capital Management's largest Q4 2025 buy was Immunome: 1,126,210 shares worth $24.2M.
  • Silverarc Capital Management added most to Celcuity in Q4 2025, an estimated $23.5M increase.
  • Silverarc Capital Management's biggest Q4 2025 reduction was Rhythm Pharmaceuticals, cutting an estimated $24.8M.
  • Silverarc Capital Management fully exited Avidity Biosciences in Q4 2025, selling an estimated $36.8M.
  • Silverarc Capital Management's ten largest holdings make up 50% of its $720M portfolio in Q4 2025.
  • Silverarc Capital Management opened 21 new positions and closed 35 in Q4 2025.
  • Silverarc Capital Management's portfolio value fell 2.9% quarter-over-quarter to $720M.

Based on Silverarc Capital Management's 13F filing for Q4 2025, filed 12 Feb 2026.