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Rock Springs Capital Management Portfolio holdings

AUM $2.05B
1-Year Est. Return 161.37%
This Fund
S&P 500
This Quarter Est. Return
+4.87%
1 Year Est. Return
+161.37%
3 Year Est. Return
+342.48%
5 Year Est. Return
+531.16%
10 Year Est. Return
+6,258.71%
AUM
$1.7B
AUM Growth
-$254M
Cap. Flow
-$154M
Cap. Flow %
-9.05%
Top 10 Hldgs %
40.6%
Holding
107
New
9
Increased
39
Reduced
24
Closed
7

Top Buys

Rank Stock Value
1
MMED
MiniMed Group Inc
MMED
+$17.4M
2
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$15M
3
BSX icon
Boston Scientific
BSX
+$9.3M
4
HTFL
Heartflow Inc
HTFL
+$8M
5
PTCT icon
PTC Therapeutics
PTCT
+$7.08M

Top Sells

Rank Stock Value
1
EXAS
Exact Sciences
EXAS
+$61.1M
2
CDTX
Cidara Therapeutics
CDTX
+$45.3M
3
FOLD
Amicus Therapeutics
FOLD
+$27.4M
4
XBI icon
State Street SPDR S&P Biotech ETF
XBI
+$24M
5
TVTX icon
Travere Therapeutics
TVTX
+$21.9M

Sector Composition

Rank Sector Weight
1 Healthcare 99.77%
2 Miscellaneous 0.23%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CDTX
101
DELISTED
Cidara Therapeutics
CDTX
– –
-204,878
Closed -$45.3M
EXAS
102
DELISTED
Exact Sciences
EXAS
– –
-601,800
Closed -$61.1M
MRSN
103
DELISTED
Mersana Therapeutics
MRSN
– –
-152,586
Closed -$4.41M
NAMS icon
104
CALL
NewAmsterdam Pharma
NAMS
$3.1B
– –
-31,600
Closed -$1.11M
NUVB.WS
105
DELISTED
Nuvation Bio Inc Warrants
NUVB.WS
– –
-134,028
Closed -$44.2K
RAPT
106
DELISTED
RAPT Therapeutics
RAPT
– –
-213,731
Closed -$7.24M
TBPH icon
107
Theravance Biopharma
TBPH
$885M
– –
-208,771
Closed -$3.91M
1 2 3 4
5

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Rock Springs Capital Management's Q1 2026 Portfolio in Review

As of Q1 2026, Rock Springs Capital Management held 107 positions worth $1.7B, down 13% from $1.95B the previous quarter. Its ten largest holdings account for 41% of the portfolio.

Rock Springs Capital Management withdrew a net $154M in Q1 2026, closing 7 positions and reducing 24 holdings. Its most notable exit was Exact Sciences, an estimated $61.1M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 98% a quarter earlier, followed by Miscellaneous.

Against the trend, Rock Springs Capital Management opened a new position in MiniMed Group Inc worth $15.7M.

  • Rock Springs Capital Management's largest Q1 2026 buy was MiniMed Group Inc: 1,055,000 shares worth $15.7M.
  • Rock Springs Capital Management added most to Madrigal Pharmaceuticals in Q1 2026, an estimated $15M increase.
  • Rock Springs Capital Management's biggest Q1 2026 reduction was Amicus Therapeutics, cutting an estimated $27.4M.
  • Rock Springs Capital Management fully exited Exact Sciences in Q1 2026, selling an estimated $61.1M.
  • Rock Springs Capital Management's ten largest holdings make up 41% of its $1.7B portfolio in Q1 2026.
  • Rock Springs Capital Management opened 9 new positions and closed 7 in Q1 2026.
  • Rock Springs Capital Management's portfolio value fell 13% quarter-over-quarter to $1.7B.

Based on Rock Springs Capital Management's 13F filing for Q1 2026, filed 15 May 2026.