John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$510M |
| 2 |
Broadcom
AVGO
|
+$318M |
| 3 |
Marvell Technology
MRVL
|
+$290M |
| 4 |
Salesforce
CRM
|
+$263M |
| 5 |
Advanced Micro Devices
AMD
|
+$250M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Eli Lilly
LLY
|
+$255M |
| 2 |
Progressive
PGR
|
+$244M |
| 3 |
Visa
V
|
+$238M |
| 4 |
Lam Research
LRCX
|
+$201M |
| 5 |
Elevance Health
ELV
|
+$190M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 17.88% |
| 2 | Healthcare | 13.28% |
| 3 | Financials | 10.32% |
| 4 | Industrials | 9.79% |
| 5 | Consumer Discretionary | 8.58% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
26
DoorDash
DASH
$96.8B
| $231M | 0.49% |
1,261,677
-263,784
| -17% | -$49.6M |
|
27
State Street Health Care Select Sector SPDR ETF
XLV
$45.5B
| $228M | 0.49% |
1,559,500
-811,857
| -34% | -$118M |
|
28
Humana
HUM
$45.5B
| $227M | 0.48% |
856,776
+269,723
| +46% | +$72.9M |
|
29
Danaher
DHR
$154B
| $227M | 0.48% |
1,105,601
+78,106
| +8% | +$17.1M |
|
30
Dollar General
DG
$27.2B
| $225M | 0.48% |
2,556,870
+202,735
| +9% | +$15.3M |
|
31
Microsoft
MSFT
$3.59T
| $223M | 0.48% |
594,754
-6,015
| -1% | -$2.45M |
|
32
Mastercard
MA
$509B
| $223M | 0.48% |
406,423
-17,114
| -4% | -$9.32M |
|
33
Gartner
IT
$12.4B
| $220M | 0.47% |
523,260
+433,733
| +484% | +$214M |
|
34
McKesson
MCK
$100B
| $219M | 0.47% |
325,934
+161,193
| +98% | +$99.7M |
|
|
NVO
35
Novo Nordisk
NVO
$207B
| $219M | 0.47% |
3,147,929
+1,303,506
| +71% | +$108M |
|
36
IQVIA
IQV
$42.8B
| $216M | 0.46% |
1,226,405
+458,426
| +60% | +$88.9M |
|
37
Centene
CNC
$32.1B
| $216M | 0.46% |
3,556,336
+1,310,825
| +58% | +$79.2M |
|
38
Mercado Libre
MELI
$97.5B
| $215M | 0.46% |
110,229
+103,276
| +1,485% | +$205M |
|
39
Arista Networks
ANET
$238B
| $214M | 0.46% |
2,767,058
+2,306,967
| +501% | +$234M |
|
40
Intercontinental Exchange
ICE
$90.5B
| $214M | 0.46% |
1,239,002
+246,658
| +25% | +$40.4M |
|
41
Intuitive Surgical
ISRG
$134B
| $204M | 0.44% |
411,661
+343,351
| +503% | +$190M |
|
42
Fortinet
FTNT
$113B
| $202M | 0.43% |
2,098,119
-65,688
| -3% | -$6.66M |
|
43
Linde
LIN
$225B
| $200M | 0.43% |
429,725
+300,602
| +233% | +$135M |
|
44
Merck
MRK
$376B
| $198M | 0.42% |
2,200,701
+271,872
| +14% | +$25.4M |
|
45
Netflix
NFLX
$331B
| $197M | 0.42% |
2,112,380
-684,390
| -24% | -$65.1M |
|
|
WCN
46
Waste Connections
WCN
$42.6B
| $196M | 0.42% |
1,003,328
+30,377
| +3% | +$5.62M |
|
47
Northrop Grumman
NOC
$78.3B
| $192M | 0.41% |
374,247
-69,416
| -16% | -$33.1M |
|
48
ServiceNow
NOW
$133B
| $190M | 0.41% |
1,192,175
+1,170,150
| +5,313% | +$226M |
|
|
SPYM
49
State Street SPDR Portfolio S&P 500 ETF
SPYM
$169B
| $189M | 0.4% |
2,878,700
-558,900
| -16% | -$38.7M |
|
50
Meta Platforms (Facebook)
META
$1.4T
| $189M | 0.4% |
328,386
-77,844
| -19% | -$50.2M |
|
Similar funds
John Overdeck's Q1 2025 Portfolio in Review
As of Q1 2025, John Overdeck held 3,617 positions worth $46.8B, up 2% from $45.9B the previous quarter. Its ten largest holdings account for 8.1% of the portfolio.
John Overdeck deployed $2.08B of net new capital in Q1 2025, opening 458 new positions and adding to 1,225 existing holdings. Its largest new stake was Advanced Micro Devices: 2,246,952 shares worth $231M.
By sector, the portfolio is most concentrated in Technology at 18% of assets, up from 16% a quarter earlier, followed by Healthcare and Financials.
On the sell side, the largest reduction was Eli Lilly, an estimated $255M trimmed.
- John Overdeck's largest Q1 2025 buy was Advanced Micro Devices: 2,246,952 shares worth $231M.
- John Overdeck added most to State Street SPDR S&P 500 ETF Trust in Q1 2025, an estimated $510M increase.
- John Overdeck's biggest Q1 2025 reduction was Eli Lilly, cutting an estimated $255M.
- John Overdeck fully exited Coinbase in Q1 2025, selling an estimated $45M.
- John Overdeck's ten largest holdings make up 8.1% of its $46.8B portfolio in Q1 2025.
- John Overdeck opened 458 new positions and closed 452 in Q1 2025.
- John Overdeck's portfolio value rose 2% quarter-over-quarter to $46.8B.
Based on Two Sigma Investments's 13F filing for Q1 2025, filed 15 May 2025.