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JO

John Overdeck Two Sigma Investments

AUM $138B
1-Year Est. Return 41.87%
 

John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.

This Fund
S&P 500
This Quarter Est. Return
+3.47%
1 Year Est. Return
+41.87%
3 Year Est. Return
+122.61%
5 Year Est. Return
+129.48%
10 Year Est. Return
+649.67%
AUM
$70.9B
AUM Growth
+$3.72B
Cap. Flow
+$541M
Cap. Flow %
0.76%
Top 10 Hldgs %
4.9%
Holding
4,545
New
899
Increased
1,598
Reduced
1,287
Closed
504

Sector Composition

Rank Sector Weight
1 Technology 15.53%
2 Financials 13%
3 Industrials 11.22%
4 Healthcare 10.29%
5 Consumer Discretionary 9.16%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake
Capital Flow
CTM icon
3801
Castellum
CTM
$57.6M
$68.1K ﹤0.01%
75,384
-2,181
-3% -$2.33K
KAPA
3802
Kairos Pharma
KAPA
$5.45M
$66.7K ﹤0.01%
94,008
+48,219
+105% +$45.1K
IPM
3803
Intelligent Protection Management Corp
IPM
$16.7M
$66.5K ﹤0.01%
+38,677
New +$73.8K
INAB icon
3804
IN8bio
INAB
$11.7M
$66K ﹤0.01%
28,214
-21,239
-43% -$40.4K
EPOW icon
3805
E-Power Inc
EPOW
$16.9M
$66K ﹤0.01%
+67,304
New +$76.4K
ALTG icon
3806
Alta Equipment Group
ALTG
$210M
$65.1K ﹤0.01%
14,148
-10,052
-42% -$55.2K
PALI icon
3807
Palisade Bio
PALI
$356M
$65K ﹤0.01%
+27,640
New +$53.1K
AQB icon
3808
AquaBounty Technologies
AQB
$6.74M
$64.9K ﹤0.01%
69,789
+32,224
+86% +$40.6K
CDXS icon
3809
Codexis
CDXS
$188M
$64.9K ﹤0.01%
39,804
+17,059
+75% +$34.8K
SERA icon
3810
Sera Prognostics
SERA
$84.8M
$64.8K ﹤0.01%
21,964
-9,772
-31% -$31.5K
CGTX icon
3811
Cognition Therapeutics
CGTX
$93.7M
$64.4K ﹤0.01%
47,729
-49,262
-51% -$80K
DARE icon
3812
Dare Bioscience
DARE
$15.5M
$63.8K ﹤0.01%
+33,036
New +$65.9K
ARAI
3813
Arrive AI Inc
ARAI
$12.5M
$63.7K ﹤0.01%
24,227
-5,000
-17% -$20.9K
SIGA icon
3814
SIGA Technologies
SIGA
$213M
$63.5K ﹤0.01%
+10,400
New +$74K
WEST icon
3815
Westrock Coffee
WEST
$837M
$63.1K ﹤0.01%
15,494
-500
-3% -$2.19K
KTTA icon
3816
Pasithea Therapeutics
KTTA
$18M
$62.9K ﹤0.01%
48,773
+13,013
+36% +$11.4K
BNGO icon
3817
Bionano Genomics
BNGO
$14.1M
$62K ﹤0.01%
+40,513
New +$70.1K
CNVS icon
3818
Cineverse
CNVS
$59.7M
$61.7K ﹤0.01%
29,245
-131,386
-82% -$356K
ORIO
3819
Orion Digital Corp
ORIO
$20.1M
$60.6K ﹤0.01%
56,633
-64,746
-53% -$92.1K
TCRT icon
3820
Alaunos Therapeutics
TCRT
$4.5M
$60K ﹤0.01%
+18,588
New +$60.1K
FGNX
3821
FG Nexus Inc
FGNX
$37.4M
$59.9K ﹤0.01%
+4,356
New +$76.4K
NMAD
3822
Nomad Power Solutions
NMAD
$79M
$59.6K ﹤0.01%
+15,174
New +$65.6K
LINK icon
3823
Interlink Electronics
LINK
$82.7M
$59.1K ﹤0.01%
+15,242
New +$78.9K
AUID icon
3824
authID Inc
AUID
$7.66M
$58.7K ﹤0.01%
+67,076
New +$127K
DWSN icon
3825
Dawson Geophysical
DWSN
$103M
$58.4K ﹤0.01%
37,416
+7,991
+27% +$15.1K

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John Overdeck's Q4 2025 Portfolio in Review

As of Q4 2025, John Overdeck held 4,545 positions worth $70.9B, up 5.5% from $67.2B the previous quarter. Its ten largest holdings account for 4.9% of the portfolio.

John Overdeck's Q4 2025 filing shows 899 new, 1,598 increased, 1,287 reduced and 504 closed positions. Its largest new stake was Vanguard Real Estate ETF: 3,573,400 shares worth $316M. The largest sale was State Street Financial Select Sector SPDR ETF, an estimated $547M.

By sector, the portfolio is most concentrated in Technology at 16% of assets, down from 16% a quarter earlier, followed by Financials and Industrials.

  • John Overdeck's largest Q4 2025 buy was Vanguard Real Estate ETF: 3,573,400 shares worth $316M.
  • John Overdeck added most to State Street Technology Select Sector SPDR ETF in Q4 2025, an estimated $395M increase.
  • John Overdeck's biggest Q4 2025 reduction was State Street Financial Select Sector SPDR ETF, cutting an estimated $547M.
  • John Overdeck fully exited State Street SPDR Dow Jones Industrial Average ETF Trust in Q4 2025, selling an estimated $240M.
  • John Overdeck's ten largest holdings make up 4.9% of its $70.9B portfolio in Q4 2025.
  • John Overdeck opened 899 new positions and closed 504 in Q4 2025.
  • John Overdeck's portfolio value rose 5.5% quarter-over-quarter to $70.9B.

Based on Two Sigma Investments's 13F filing for Q4 2025, filed 17 Feb 2026.