John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street Financial Select Sector SPDR ETF
XLF
|
+$474M |
| 2 |
State Street Consumer Staples Select Sector SPDR ETF
XLP
|
+$357M |
| 3 |
Accenture
ACN
|
+$246M |
| 4 |
Advanced Micro Devices
AMD
|
+$235M |
| 5 |
State Street SPDR Dow Jones Industrial Average ETF Trust
DIA
|
+$231M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Invesco QQQ Trust
QQQ
|
+$381M |
| 2 |
State Street Technology Select Sector SPDR ETF
XLK
|
+$375M |
| 3 |
iShares Expanded Tech-Software Sector ETF
IGV
|
+$348M |
| 4 |
Thermo Fisher Scientific
TMO
|
+$292M |
| 5 |
Snowflake
SNOW
|
+$258M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 16.18% |
| 2 | Financials | 15.54% |
| 3 | Industrials | 10.5% |
| 4 | Healthcare | 9.8% |
| 5 | Consumer Discretionary | 8.1% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
3526
Myomo
MYO
$68.5M
| $16.9K | ﹤0.01% |
18,890
-132,865
| -88% | -$193K |
|
3527
Smith Micro Software
SMSI
$16.7M
| $16.4K | ﹤0.01% |
4,548
-1,614
| -26% | -$6.25K |
|
3528
Incannex Healthcare
IXHL
$42.7M
| $15.7K | ﹤0.01% |
+1,129
| New | +$18.3K |
|
3529
Singularity Future Technology
SGLY
$2.31M
| $15.5K | ﹤0.01% |
+828
| New | +$12.4K |
|
3530
Integrated Media Technology
IMTE
$1.76M
| $15.4K | ﹤0.01% |
+15,476
| New | +$16.3K |
|
3531
Gogoro
GGR
$45.6M
| $15.4K | ﹤0.01% |
2,557
-1,339
| -34% | -$9.35K |
|
3532
Trio Petroleum
TPET
$9.16M
| $15.2K | ﹤0.01% |
+14,510
| New | +$16.8K |
|
3533
Aethlon Medical
AEMD
$1.94M
| $15.2K | ﹤0.01% |
+405
| New | +$23.3K |
|
3534
Barnwell Industries
BRN
$14.2M
| $14.8K | ﹤0.01% |
+11,416
| New | +$13.3K |
|
|
XHLD
3535
TEN Holdings
XHLD
$91.7M
| $14.8K | ﹤0.01% |
2,760
-301
| -10% | -$1.57K |
|
|
USBC
3536
USBC Inc
USBC
$160M
| $14.6K | ﹤0.01% |
+10,872
| New | +$19.6K |
|
3537
Maison Solutions
MSS
$1.29M
| $14.5K | ﹤0.01% |
255
-113
| -31% | -$5.23K |
|
|
SOPA
3538
DELISTED
Society Pass
SOPA
| $14.5K | ﹤0.01% |
+12,254
| New | +$15.3K |
|
|
KAVL
3539
DELISTED
Kaival Brands Innovations Group
KAVL
| $13.9K | ﹤0.01% |
+32,552
| New | +$20.4K |
|
|
CAPS
3540
Capstone Holding Corp
CAPS
$3.89M
| $13.8K | ﹤0.01% |
10,525
+226
| +2% | +$309 |
|
3541
AGAPE ATP
ATPC
$2.45M
| $13.7K | ﹤0.01% |
217
-5
| -2% | -$333 |
|
3542
AtlasClear
ATCH
$29.3M
| $12.4K | ﹤0.01% |
+24,266
| New | +$7.73K |
|
3543
Outlook Therapeutics
OTLK
$157M
| $12K | ﹤0.01% |
+11,356
| New | +$19.6K |
|
3544
Enlivex Ltd
ENLV
$25.7M
| $11.2K | ﹤0.01% |
+716
| New | +$12.9K |
|
3545
Rallybio
RLYB
$89.4M
| $10.7K | ﹤0.01% |
2,682
-5,291
| -66% | -$22.2K |
|
3546
BiomX
PHGE
$3.65M
| $10K | ﹤0.01% |
+1,007
| New | +$9.29K |
|
|
RVPH
3547
DELISTED
REVIVA PHARMA HLDGS INC
RVPH
| $8.03K | ﹤0.01% |
1,089
-323
| -23% | -$2.75K |
|
|
ORIS
3548
DELISTED
Oriental Rise Holdings
ORIS
| $7.92K | ﹤0.01% |
+529
| New | +$10.3K |
|
3549
ProMIS Neurosciences
PMN
$130M
| $7.83K | ﹤0.01% |
+737
| New | +$10.2K |
|
|
BLMZ
3550
DELISTED
Harrison Global Holdings
BLMZ
| $2.56K | ﹤0.01% |
+1,177
| New | +$2.19K |
|
Similar funds
John Overdeck's Q3 2025 Portfolio in Review
As of Q3 2025, John Overdeck held 4,027 positions worth $67.2B, up 19% from $56.5B the previous quarter. Its ten largest holdings account for 6.2% of the portfolio.
John Overdeck deployed $4.46B of net new capital in Q3 2025, opening 877 new positions and adding to 1,461 existing holdings. Its largest new stake was Berkshire Hathaway Class B: 379,096 shares worth $191M.
By sector, the portfolio is most concentrated in Technology at 16% of assets, down from 17% a quarter earlier, followed by Financials and Industrials.
On the sell side, the largest reduction was Invesco QQQ Trust, an estimated $381M trimmed.
- John Overdeck's largest Q3 2025 buy was Berkshire Hathaway Class B: 379,096 shares worth $191M.
- John Overdeck added most to State Street Financial Select Sector SPDR ETF in Q3 2025, an estimated $474M increase.
- John Overdeck's biggest Q3 2025 reduction was Invesco QQQ Trust, cutting an estimated $381M.
- John Overdeck fully exited NextEra Energy, Inc. 6.926% Corporate Units in Q3 2025, selling an estimated $115M.
- John Overdeck's ten largest holdings make up 6.2% of its $67.2B portfolio in Q3 2025.
- John Overdeck opened 877 new positions and closed 399 in Q3 2025.
- John Overdeck's portfolio value rose 19% quarter-over-quarter to $67.2B.
Based on Two Sigma Investments's 13F filing for Q3 2025, filed 14 Nov 2025.