John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street Financial Select Sector SPDR ETF
XLF
|
+$474M |
| 2 |
State Street Consumer Staples Select Sector SPDR ETF
XLP
|
+$357M |
| 3 |
Accenture
ACN
|
+$246M |
| 4 |
Advanced Micro Devices
AMD
|
+$235M |
| 5 |
State Street SPDR Dow Jones Industrial Average ETF Trust
DIA
|
+$231M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Invesco QQQ Trust
QQQ
|
+$381M |
| 2 |
State Street Technology Select Sector SPDR ETF
XLK
|
+$375M |
| 3 |
iShares Expanded Tech-Software Sector ETF
IGV
|
+$348M |
| 4 |
Thermo Fisher Scientific
TMO
|
+$292M |
| 5 |
Snowflake
SNOW
|
+$258M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 16.18% |
| 2 | Financials | 15.54% |
| 3 | Industrials | 10.5% |
| 4 | Healthcare | 9.8% |
| 5 | Consumer Discretionary | 8.1% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
|
GCL
3476
GCL Global Holdings
GCL
$97.4M
| $41.7K | ﹤0.01% |
+16,624
| New | +$55.9K |
|
3477
374Water
SCWO
$42.5M
| $41.1K | ﹤0.01% |
+14,325
| New | +$39.2K |
|
3478
Traws Pharma
TRAW
$8.19M
| $40.7K | ﹤0.01% |
22,018
+5,955
| +37% | +$9.71K |
|
3479
Werewolf Therapeutics
HOWL
$40.8M
| $39.7K | ﹤0.01% |
20,139
-25,283
| -56% | -$34.6K |
|
3480
Alto Ingredients
ALTO
$330M
| $39.3K | ﹤0.01% |
36,386
-22,209
| -38% | -$25K |
|
3481
Mega Matrix
MPU
$15.3M
| $38.8K | ﹤0.01% |
+32,321
| New | +$75.9K |
|
3482
Advantage Solutions
ADV
$436M
| $35.3K | ﹤0.01% |
+922
| New | +$38.3K |
|
|
RJET
3483
Republic Airways Holdings
RJET
$880M
| $34.2K | ﹤0.01% |
1,753
-30
| -2% | -$530 |
|
3484
Montauk Renewables
MNTK
$265M
| $34.1K | ﹤0.01% |
+16,955
| New | +$36.3K |
|
3485
Celularity
CELU
$23.2M
| $33.5K | ﹤0.01% |
16,204
| – | – |
|
3486
Beamr Imaging
BMR
$20.2M
| $33.4K | ﹤0.01% |
+10,900
| New | +$33.3K |
|
3487
Kiora Pharmaceuticals
KPRX
$11.8M
| $33.3K | ﹤0.01% |
+11,984
| New | +$32.9K |
|
3488
Marker Therapeutics
MRKR
$25.5M
| $32.6K | ﹤0.01% |
+36,540
| New | +$45.1K |
|
|
CYPH
3489
Cypherpunk Technologies Inc
CYPH
$189M
| $32.2K | ﹤0.01% |
70,849
+56,952
| +410% | +$18K |
|
|
SBFM
3490
Sunshine Biopharma
SBFM
$4.34M
| $31.9K | ﹤0.01% |
+2,140
| New | +$31.7K |
|
3491
Cheetah Net Supply Chain Service
CTNT
$4.9M
| $31.6K | ﹤0.01% |
+89
| New | +$29.1K |
|
3492
VerifyMe
VRME
$9.68M
| $31.4K | ﹤0.01% |
35,321
+24,793
| +235% | +$21.6K |
|
3493
Cyclerion Therapeutics
CYCN
$19.9M
| $30.6K | ﹤0.01% |
+13,293
| New | +$36.1K |
|
|
MURA
3494
DELISTED
Mural Oncology
MURA
| $30.4K | ﹤0.01% |
14,706
-15,892
| -52% | -$34.2K |
|
|
OLPX
3495
DELISTED
Olaplex Holdings
OLPX
| $29.9K | ﹤0.01% |
22,817
-105,339
| -82% | -$151K |
|
3496
SunPower Inc
SPWR
$54.5M
| $29.5K | ﹤0.01% |
+16,765
| New | +$27.7K |
|
3497
Galmed Pharmaceuticals
GLMD
$4.15M
| $29.3K | ﹤0.01% |
+2,650
| New | +$34K |
|
3498
Addentax Group
ATXG
$4.06M
| $29.2K | ﹤0.01% |
+1,947
| New | +$18.1K |
|
3499
Cheche Group
CCG
$41.3M
| $29.1K | ﹤0.01% |
661
-18
| -3% | -$592 |
|
|
RKTO
3500
Rocket One Inc
RKTO
$18M
| $28.1K | ﹤0.01% |
17,346
+6,247
| +56% | +$8.84K |
|
Similar funds
John Overdeck's Q3 2025 Portfolio in Review
As of Q3 2025, John Overdeck held 4,027 positions worth $67.2B, up 19% from $56.5B the previous quarter. Its ten largest holdings account for 6.2% of the portfolio.
John Overdeck deployed $4.46B of net new capital in Q3 2025, opening 877 new positions and adding to 1,461 existing holdings. Its largest new stake was Berkshire Hathaway Class B: 379,096 shares worth $191M.
By sector, the portfolio is most concentrated in Technology at 16% of assets, down from 17% a quarter earlier, followed by Financials and Industrials.
On the sell side, the largest reduction was Invesco QQQ Trust, an estimated $381M trimmed.
- John Overdeck's largest Q3 2025 buy was Berkshire Hathaway Class B: 379,096 shares worth $191M.
- John Overdeck added most to State Street Financial Select Sector SPDR ETF in Q3 2025, an estimated $474M increase.
- John Overdeck's biggest Q3 2025 reduction was Invesco QQQ Trust, cutting an estimated $381M.
- John Overdeck fully exited NextEra Energy, Inc. 6.926% Corporate Units in Q3 2025, selling an estimated $115M.
- John Overdeck's ten largest holdings make up 6.2% of its $67.2B portfolio in Q3 2025.
- John Overdeck opened 877 new positions and closed 399 in Q3 2025.
- John Overdeck's portfolio value rose 19% quarter-over-quarter to $67.2B.
Based on Two Sigma Investments's 13F filing for Q3 2025, filed 14 Nov 2025.