John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street Financial Select Sector SPDR ETF
XLF
|
+$474M |
| 2 |
State Street Consumer Staples Select Sector SPDR ETF
XLP
|
+$357M |
| 3 |
Accenture
ACN
|
+$246M |
| 4 |
Advanced Micro Devices
AMD
|
+$235M |
| 5 |
State Street SPDR Dow Jones Industrial Average ETF Trust
DIA
|
+$231M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Invesco QQQ Trust
QQQ
|
+$381M |
| 2 |
State Street Technology Select Sector SPDR ETF
XLK
|
+$375M |
| 3 |
iShares Expanded Tech-Software Sector ETF
IGV
|
+$348M |
| 4 |
Thermo Fisher Scientific
TMO
|
+$292M |
| 5 |
Snowflake
SNOW
|
+$258M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 16.18% |
| 2 | Financials | 15.54% |
| 3 | Industrials | 10.5% |
| 4 | Healthcare | 9.8% |
| 5 | Consumer Discretionary | 8.1% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
3301
Neuropace
NPCE
$480M
| $199K | ﹤0.01% |
19,293
-69,345
| -78% | -$654K |
|
3302
Comstock
LODE
$268M
| $198K | ﹤0.01% |
+58,000
| New | +$181K |
|
|
UPB
3303
Upstream Bio Inc
UPB
$362M
| $198K | ﹤0.01% |
+10,500
| New | +$163K |
|
3304
Universal Safety Products Inc
UUU
$19.6M
| $198K | ﹤0.01% |
+49,499
| New | +$210K |
|
3305
BV Financial
BVFL
$180M
| $196K | ﹤0.01% |
+12,183
| New | +$197K |
|
3306
Delcath Systems
DCTH
$581M
| $194K | ﹤0.01% |
+18,006
| New | +$201K |
|
3307
Amcor
AMCR
$22.2B
| $192K | ﹤0.01% |
4,683
-1,172,515
| -100% | -$52.6M |
|
|
HYFT
3308
MindWalk Holdings
HYFT
$64.8M
| $191K | ﹤0.01% |
108,933
+18,078
| +20% | +$35.4K |
|
3309
Microbot Medical
MBOT
$99.4M
| $190K | ﹤0.01% |
62,401
-6,547
| -9% | -$20.4K |
|
3310
Equillium
EQ
$139M
| $190K | ﹤0.01% |
+133,004
| New | +$141K |
|
3311
Ceragon Networks
CRNT
$188M
| $190K | ﹤0.01% |
81,538
-339,512
| -81% | -$748K |
|
|
WKEY
3312
WISeKey
WKEY
$75M
| $186K | ﹤0.01% |
+29,320
| New | +$170K |
|
3313
Energy Vault
NRGV
$662M
| $182K | ﹤0.01% |
+61,289
| New | +$101K |
|
3314
ADC Therapeutics
ADCT
$123M
| $182K | ﹤0.01% |
+45,458
| New | +$143K |
|
3315
Arbe Robotics
ARBE
$86.2M
| $180K | ﹤0.01% |
109,283
+21,990
| +25% | +$32.1K |
|
3316
Destination XL Group
DXLG
$35.2M
| $179K | ﹤0.01% |
136,703
+53,773
| +65% | +$70.5K |
|
|
IRD
3317
Opus Genetics
IRD
$335M
| $179K | ﹤0.01% |
108,338
+68,148
| +170% | +$84.7K |
|
|
STUB
3318
StubHub Holdings
STUB
$2.55B
| $177K | ﹤0.01% |
+10,500
| New | +$193K |
|
3319
Compañía de Cervecerías Unidas
CCU
$2.34B
| $177K | ﹤0.01% |
14,571
-51,984
| -78% | -$636K |
|
3320
Kenvue
KVUE
$37.3B
| $176K | ﹤0.01% |
+10,868
| New | +$222K |
|
3321
Alta Equipment Group
ALTG
$208M
| $175K | ﹤0.01% |
+24,200
| New | +$188K |
|
3322
NRX Pharmaceuticals
NRXP
$149M
| $173K | ﹤0.01% |
52,332
+20,880
| +66% | +$59.8K |
|
|
FMST
3323
Foremost Lithium Resource & Technology
FMST
$20M
| $172K | ﹤0.01% |
+58,850
| New | +$170K |
|
3324
Alset
AEI
$61.1M
| $171K | ﹤0.01% |
+67,777
| New | +$116K |
|
3325
SoundThinking
SSTI
$79.2M
| $171K | ﹤0.01% |
14,152
-23,958
| -63% | -$298K |
|
Similar funds
John Overdeck's Q3 2025 Portfolio in Review
As of Q3 2025, John Overdeck held 4,027 positions worth $67.2B, up 19% from $56.5B the previous quarter. Its ten largest holdings account for 6.2% of the portfolio.
John Overdeck deployed $4.46B of net new capital in Q3 2025, opening 877 new positions and adding to 1,461 existing holdings. Its largest new stake was Berkshire Hathaway Class B: 379,096 shares worth $191M.
By sector, the portfolio is most concentrated in Technology at 16% of assets, down from 17% a quarter earlier, followed by Financials and Industrials.
On the sell side, the largest reduction was Invesco QQQ Trust, an estimated $381M trimmed.
- John Overdeck's largest Q3 2025 buy was Berkshire Hathaway Class B: 379,096 shares worth $191M.
- John Overdeck added most to State Street Financial Select Sector SPDR ETF in Q3 2025, an estimated $474M increase.
- John Overdeck's biggest Q3 2025 reduction was Invesco QQQ Trust, cutting an estimated $381M.
- John Overdeck fully exited NextEra Energy, Inc. 6.926% Corporate Units in Q3 2025, selling an estimated $115M.
- John Overdeck's ten largest holdings make up 6.2% of its $67.2B portfolio in Q3 2025.
- John Overdeck opened 877 new positions and closed 399 in Q3 2025.
- John Overdeck's portfolio value rose 19% quarter-over-quarter to $67.2B.
Based on Two Sigma Investments's 13F filing for Q3 2025, filed 14 Nov 2025.