John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$510M |
| 2 |
Broadcom
AVGO
|
+$318M |
| 3 |
Marvell Technology
MRVL
|
+$290M |
| 4 |
Salesforce
CRM
|
+$263M |
| 5 |
Advanced Micro Devices
AMD
|
+$250M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Eli Lilly
LLY
|
+$255M |
| 2 |
Progressive
PGR
|
+$244M |
| 3 |
Visa
V
|
+$238M |
| 4 |
Lam Research
LRCX
|
+$201M |
| 5 |
Elevance Health
ELV
|
+$190M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 17.88% |
| 2 | Healthcare | 13.28% |
| 3 | Financials | 10.32% |
| 4 | Industrials | 9.79% |
| 5 | Consumer Discretionary | 8.58% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
|
WCT
3051
Wellchange Holdings
WCT
$4.2M
| $16.2K | ﹤0.01% |
+1,802
| New | +$150K |
|
|
ZJYL
3052
Jin Medical International
ZJYL
$228M
| $15.6K | ﹤0.01% |
1,047
-593
| -36% | -$9.87K |
|
|
LNAI
3053
Lunai Bioworks
LNAI
$9.66M
| $15.4K | ﹤0.01% |
354
+57
| +19% | +$3.65K |
|
3054
Odyssey Marine Exploration
OMEX
$52.7M
| $14.8K | ﹤0.01% |
36,884
+1,762
| +5% | +$899 |
|
3055
Usio Inc
USIO
$82.6M
| $14.7K | ﹤0.01% |
+10,035
| New | +$18.1K |
|
|
EONR
3056
EON Resources
EONR
$24.3M
| $13.6K | ﹤0.01% |
+28,292
| New | +$20.2K |
|
3057
Pixelworks
PXLW
$40.5M
| $13.6K | ﹤0.01% |
1,803
-776
| -30% | -$7.14K |
|
|
JUNS
3058
Jupiter Neurosciences
JUNS
$4.35M
| $13.3K | ﹤0.01% |
+290
| New | +$47.1K |
|
3059
Garden Stage Ltd
GSIW
$23.6M
| $12.1K | ﹤0.01% |
126
| – | – |
|
|
RKTO
3060
Rocket One Inc
RKTO
$18.3M
| $11.2K | ﹤0.01% |
11,247
+147
| +1% | +$175 |
|
3061
FibroBiologics
FBLG
$9.19M
| $11.1K | ﹤0.01% |
616
+113
| +22% | +$3.23K |
|
3062
Scilex Holding
SCLX
$40.2M
| $11K | ﹤0.01% |
1,270
-473
| -27% | -$5.94K |
|
|
FLYE
3063
Fly-E Group
FLYE
$2.66M
| $11K | ﹤0.01% |
253
| – | – |
|
3064
iPower
IPW
$483K
| $10.3K | ﹤0.01% |
10
-14
| -58% | -$20.6K |
|
3065
Sol-Gel Technologies
SLGL
$254M
| $9.36K | ﹤0.01% |
+1,800
| New | +$13.3K |
|
|
MHUA
3066
DELISTED
Meihua International Medical Technologies
MHUA
| $9.34K | ﹤0.01% |
278
-26
| -9% | -$857 |
|
|
MBAI
3067
Check-Cap
MBAI
$11M
| $9.09K | ﹤0.01% |
+1,641
| New | +$11.3K |
|
3068
IT Tech Packaging
ITP
$2.95M
| $8.62K | ﹤0.01% |
31,461
+20,000
| +175% | +$7.33K |
|
|
TRIB
3069
Trinity Biotech
TRIB
$8.61M
| $8.59K | ﹤0.01% |
+502
| New | +$11.9K |
|
3070
BioNexus Gene Lab
BGLC
$4.55M
| $8.4K | ﹤0.01% |
+3,553
| New | +$12.5K |
|
3071
Aethlon Medical
AEMD
$1.88M
| $8.13K | ﹤0.01% |
57
+1
| +2% | +$233 |
|
3072
Lucas GC Ltd
LGCL
$1.98M
| $7.81K | ﹤0.01% |
399
-65
| -14% | -$1.46K |
|
|
BSLK
3073
DELISTED
Bolt Projects Holdings
BSLK
| $7.55K | ﹤0.01% |
1,229
| – | – |
|
3074
Chanson International
CHSN
$2.64M
| $7.31K | ﹤0.01% |
+4
| New | +$47.4K |
|
|
FRSX
3075
Foresight Autonomous Holdings
FRSX
$4.79M
| $6.93K | ﹤0.01% |
+517
| New | +$10.6K |
|
Similar funds
John Overdeck's Q1 2025 Portfolio in Review
As of Q1 2025, John Overdeck held 3,617 positions worth $46.8B, up 2% from $45.9B the previous quarter. Its ten largest holdings account for 8.1% of the portfolio.
John Overdeck deployed $2.08B of net new capital in Q1 2025, opening 458 new positions and adding to 1,225 existing holdings. Its largest new stake was Advanced Micro Devices: 2,246,952 shares worth $231M.
By sector, the portfolio is most concentrated in Technology at 18% of assets, up from 16% a quarter earlier, followed by Healthcare and Financials.
On the sell side, the largest reduction was Eli Lilly, an estimated $255M trimmed.
- John Overdeck's largest Q1 2025 buy was Advanced Micro Devices: 2,246,952 shares worth $231M.
- John Overdeck added most to State Street SPDR S&P 500 ETF Trust in Q1 2025, an estimated $510M increase.
- John Overdeck's biggest Q1 2025 reduction was Eli Lilly, cutting an estimated $255M.
- John Overdeck fully exited Coinbase in Q1 2025, selling an estimated $45M.
- John Overdeck's ten largest holdings make up 8.1% of its $46.8B portfolio in Q1 2025.
- John Overdeck opened 458 new positions and closed 452 in Q1 2025.
- John Overdeck's portfolio value rose 2% quarter-over-quarter to $46.8B.
Based on Two Sigma Investments's 13F filing for Q1 2025, filed 15 May 2025.