John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$510M |
| 2 |
Broadcom
AVGO
|
+$318M |
| 3 |
Marvell Technology
MRVL
|
+$290M |
| 4 |
Salesforce
CRM
|
+$263M |
| 5 |
Advanced Micro Devices
AMD
|
+$250M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Eli Lilly
LLY
|
+$255M |
| 2 |
Progressive
PGR
|
+$244M |
| 3 |
Visa
V
|
+$238M |
| 4 |
Lam Research
LRCX
|
+$201M |
| 5 |
Elevance Health
ELV
|
+$190M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 17.88% |
| 2 | Healthcare | 13.28% |
| 3 | Financials | 10.32% |
| 4 | Industrials | 9.79% |
| 5 | Consumer Discretionary | 8.58% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
3001
GigaMedia
GIGM
$15.9M
| $39.6K | ﹤0.01% |
24,140
+20
| +0.1% | +$32 |
|
3002
Verrica Pharmaceuticals
VRCA
$84.5M
| $39.2K | ﹤0.01% |
8,867
-3,977
| -31% | -$25.7K |
|
3003
Greenland Technologies Holding
GTEC
$24.8M
| $38.5K | ﹤0.01% |
22,023
-96,578
| -81% | -$181K |
|
|
MRIN
3004
DELISTED
Marin Software
MRIN
| $37.3K | ﹤0.01% |
27,605
-5,418
| -16% | -$9.97K |
|
3005
E-Home Household Service Holdings
EJH
$4.13M
| $36.9K | ﹤0.01% |
+25
| New | +$23.7K |
|
3006
Beyond Meat
BYND
$244M
| $36.7K | ﹤0.01% |
401
-1,853
| -82% | -$205K |
|
3007
Cognition Therapeutics
CGTX
$93.8M
| $34.7K | ﹤0.01% |
82,544
+28,853
| +54% | +$17K |
|
|
HYFT
3008
MindWalk Holdings
HYFT
$65.8M
| $34.1K | ﹤0.01% |
+90,582
| New | +$40.8K |
|
3009
Biote Corp
BTMD
$45M
| $34K | ﹤0.01% |
10,204
-39,093
| -79% | -$186K |
|
3010
Newegg Commerce
NEGG
$380M
| $32.9K | ﹤0.01% |
+6,394
| New | +$51.4K |
|
3011
Gogoro
GGR
$59.8M
| $32.4K | ﹤0.01% |
6,000
-6,109
| -50% | -$51.6K |
|
|
ITRM
3012
DELISTED
Iterum Therapeutics
ITRM
| $31.1K | ﹤0.01% |
25,245
| – | – |
|
3013
Maison Solutions
MSS
$1.23M
| $30.9K | ﹤0.01% |
+599
| New | +$35.8K |
|
3014
Millennium Group International
MGIH
$18.3M
| $30.8K | ﹤0.01% |
+21,113
| New | +$34.6K |
|
3015
BuzzFeed
BZFD
$92.5M
| $29.7K | ﹤0.01% |
13,950
-132,428
| -90% | -$316K |
|
3016
Cibus
CBUS
$132M
| $29.1K | ﹤0.01% |
15,551
-9,023
| -37% | -$21.1K |
|
3017
ECARX Holdings
ECX
$428M
| $28.1K | ﹤0.01% |
+22,269
| New | +$47.6K |
|
|
ADAP
3018
DELISTED
Adaptimmune Therapeutics
ADAP
| $26.8K | ﹤0.01% |
135,947
+59,600
| +78% | +$30.9K |
|
|
PEV
3019
DELISTED
Phoenix Motor Inc. Common Stock
PEV
| $26.6K | ﹤0.01% |
76,424
+60,246
| +372% | +$21.6K |
|
3020
Skye Bioscience
SKYE
$9.61M
| $26.4K | ﹤0.01% |
+2,076
| New | +$45.3K |
|
3021
Cellectar Biosciences
CLRB
$23.7M
| $26.2K | ﹤0.01% |
2,770
+399
| +17% | +$3.61K |
|
3022
Outlook Therapeutics
OTLK
$147M
| $25.3K | ﹤0.01% |
20,719
+10,128
| +96% | +$17.8K |
|
|
LYRA
3023
DELISTED
LYRA THERAPEUTICS INC
LYRA
| $24.4K | ﹤0.01% |
3,863
-337
| -8% | -$3.15K |
|
|
BTOC
3024
Armlogi Holding Corp
BTOC
$13.4M
| $24.1K | ﹤0.01% |
+24,102
| New | +$68.2K |
|
3025
Biomerica
BMRA
$5.19M
| $24K | ﹤0.01% |
+5,295
| New | +$26.2K |
|
Similar funds
John Overdeck's Q1 2025 Portfolio in Review
As of Q1 2025, John Overdeck held 3,617 positions worth $46.8B, up 2% from $45.9B the previous quarter. Its ten largest holdings account for 8.1% of the portfolio.
John Overdeck deployed $2.08B of net new capital in Q1 2025, opening 458 new positions and adding to 1,225 existing holdings. Its largest new stake was Advanced Micro Devices: 2,246,952 shares worth $231M.
By sector, the portfolio is most concentrated in Technology at 18% of assets, up from 16% a quarter earlier, followed by Healthcare and Financials.
On the sell side, the largest reduction was Eli Lilly, an estimated $255M trimmed.
- John Overdeck's largest Q1 2025 buy was Advanced Micro Devices: 2,246,952 shares worth $231M.
- John Overdeck added most to State Street SPDR S&P 500 ETF Trust in Q1 2025, an estimated $510M increase.
- John Overdeck's biggest Q1 2025 reduction was Eli Lilly, cutting an estimated $255M.
- John Overdeck fully exited Coinbase in Q1 2025, selling an estimated $45M.
- John Overdeck's ten largest holdings make up 8.1% of its $46.8B portfolio in Q1 2025.
- John Overdeck opened 458 new positions and closed 452 in Q1 2025.
- John Overdeck's portfolio value rose 2% quarter-over-quarter to $46.8B.
Based on Two Sigma Investments's 13F filing for Q1 2025, filed 15 May 2025.