John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
iShares Expanded Tech-Software Sector ETF
IGV
|
+$312M |
| 2 |
UnitedHealth
UNH
|
+$286M |
| 3 |
Duolingo
DUOL
|
+$247M |
| 4 |
Aon
AON
|
+$226M |
| 5 |
Chubb
CB
|
+$221M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Broadcom
AVGO
|
+$338M |
| 2 |
Marvell Technology
MRVL
|
+$241M |
| 3 |
Advanced Micro Devices
AMD
|
+$240M |
| 4 |
ServiceNow
NOW
|
+$203M |
| 5 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$193M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 16.79% |
| 2 | Financials | 14.46% |
| 3 | Healthcare | 12.9% |
| 4 | Consumer Discretionary | 8.97% |
| 5 | Industrials | 8.82% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
2951
Indonesia Energy Corp
INDO
$44.6M
| $75.5K | ﹤0.01% |
+25,342
| New | +$69.8K |
|
2952
Taysha Gene Therapies
TSHA
$1.98B
| $75.5K | ﹤0.01% |
+32,682
| New | +$71K |
|
|
KYNB
2953
Kyntra Bio
KYNB
$31.4M
| $74.8K | ﹤0.01% |
14,111
-9,267
| -40% | -$67.6K |
|
2954
Resources Connection
RGP
$148M
| $74.8K | ﹤0.01% |
13,921
-43,427
| -76% | -$236K |
|
|
TEAD
2955
Teads Holding Co
TEAD
$60M
| $74K | ﹤0.01% |
+29,822
| New | +$90.2K |
|
2956
Genelux
GNLX
$120M
| $71.7K | ﹤0.01% |
24,992
-6,300
| -20% | -$16.6K |
|
2957
PepGen
PEPG
$221M
| $70.8K | ﹤0.01% |
63,740
+17,546
| +38% | +$24.8K |
|
2958
AirSculpt Technologies
AIRS
$194M
| $70.2K | ﹤0.01% |
+14,541
| New | +$49.4K |
|
2959
Precision BioSciences
DTIL
$234M
| $68.7K | ﹤0.01% |
16,363
+2,798
| +21% | +$13.8K |
|
2960
authID Inc
AUID
$7.63M
| $68.4K | ﹤0.01% |
+12,926
| New | +$75.7K |
|
2961
LG Display
LPL
$3.34B
| $67.4K | ﹤0.01% |
+19,713
| New | +$60.9K |
|
2962
Alto Ingredients
ALTO
$326M
| $67.4K | ﹤0.01% |
58,595
-87,085
| -60% | -$83.4K |
|
|
TPIC
2963
DELISTED
TPI Composites
TPIC
| $65.7K | ﹤0.01% |
76,438
-1,083
| -1% | -$1.1K |
|
2964
Actinium Pharmaceuticals
ATNM
$33.6M
| $65.2K | ﹤0.01% |
+46,545
| New | +$69.7K |
|
2965
BTCS Inc
BTCS
$72.7M
| $65.1K | ﹤0.01% |
+29,608
| New | +$62.8K |
|
|
ACB
2966
Aurora Cannabis
ACB
$255M
| $64.9K | ﹤0.01% |
15,307
+209
| +1% | +$1.01K |
|
2967
FTC Solar
FTCI
$35.2M
| $64.7K | ﹤0.01% |
14,285
| – | – |
|
2968
Smart Sand
SND
$198M
| $64.3K | ﹤0.01% |
32,013
-409
| -1% | -$828 |
|
2969
Avalo Therapeutics
AVTX
$1.04B
| $64.3K | ﹤0.01% |
+12,889
| New | +$60.2K |
|
2970
eGain
EGAN
$199M
| $63.3K | ﹤0.01% |
10,135
-17,291
| -63% | -$92.5K |
|
2971
TETRA Technologies
TTI
$1.02B
| $63.1K | ﹤0.01% |
+18,766
| New | +$54.6K |
|
2972
Immuneering
IMRX
$339M
| $62.5K | ﹤0.01% |
18,553
-17,204
| -48% | -$29.5K |
|
2973
AC Immune
ACIU
$283M
| $62.3K | ﹤0.01% |
+30,690
| New | +$53.4K |
|
|
OKUR
2974
OnKure Therapeutics
OKUR
$164M
| $61.8K | ﹤0.01% |
25,862
-1,286
| -5% | -$3.37K |
|
2975
Shattuck Labs
STTK
$797M
| $60.9K | ﹤0.01% |
76,934
-8,304
| -10% | -$8.05K |
|
Similar funds
John Overdeck's Q2 2025 Portfolio in Review
As of Q2 2025, John Overdeck held 3,681 positions worth $56.5B, up 21% from $46.8B the previous quarter. Its ten largest holdings account for 7.7% of the portfolio.
John Overdeck deployed $2.96B of net new capital in Q2 2025, opening 509 new positions and adding to 1,200 existing holdings. Its largest new stake was iShares Expanded Tech-Software Sector ETF: 3,154,300 shares worth $345M.
By sector, the portfolio is most concentrated in Technology at 17% of assets, down from 18% a quarter earlier, followed by Financials and Healthcare.
On the sell side, the largest reduction was Broadcom, an estimated $338M trimmed.
- John Overdeck's largest Q2 2025 buy was iShares Expanded Tech-Software Sector ETF: 3,154,300 shares worth $345M.
- John Overdeck added most to UnitedHealth in Q2 2025, an estimated $286M increase.
- John Overdeck's biggest Q2 2025 reduction was Broadcom, cutting an estimated $338M.
- John Overdeck fully exited State Street Utilities Select Sector SPDR ETF in Q2 2025, selling an estimated $134M.
- John Overdeck's ten largest holdings make up 7.7% of its $56.5B portfolio in Q2 2025.
- John Overdeck opened 509 new positions and closed 531 in Q2 2025.
- John Overdeck's portfolio value rose 21% quarter-over-quarter to $56.5B.
Based on Two Sigma Investments's 13F filing for Q2 2025, filed 14 Aug 2025.