John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$510M |
| 2 |
Broadcom
AVGO
|
+$318M |
| 3 |
Marvell Technology
MRVL
|
+$290M |
| 4 |
Salesforce
CRM
|
+$263M |
| 5 |
Advanced Micro Devices
AMD
|
+$250M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Eli Lilly
LLY
|
+$255M |
| 2 |
Progressive
PGR
|
+$244M |
| 3 |
Visa
V
|
+$238M |
| 4 |
Lam Research
LRCX
|
+$201M |
| 5 |
Elevance Health
ELV
|
+$190M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 17.88% |
| 2 | Healthcare | 13.28% |
| 3 | Financials | 10.32% |
| 4 | Industrials | 9.79% |
| 5 | Consumer Discretionary | 8.58% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
2876
Cosan
CSAN
$2.64B
| $118K | ﹤0.01% |
+22,649
| New | +$119K |
|
2877
Inovio Pharmaceuticals
INO
$129M
| $118K | ﹤0.01% |
+72,364
| New | +$145K |
|
2878
Liberty Latin America Class C
LILAK
$1.64B
| $117K | ﹤0.01% |
20,800
+5,070
| +32% | +$30.8K |
|
2879
indie Semiconductor
INDI
$828M
| $117K | ﹤0.01% |
57,368
-38,062
| -40% | -$132K |
|
|
OKUR
2880
OnKure Therapeutics
OKUR
$158M
| $117K | ﹤0.01% |
+27,148
| New | +$153K |
|
|
AARD
2881
Aardvark Therapeutics
AARD
$151M
| $116K | ﹤0.01% |
+15,424
| New | +$173K |
|
|
MURA
2882
DELISTED
Mural Oncology
MURA
| $115K | ﹤0.01% |
91,624
+26,474
| +41% | +$96.5K |
|
2883
Latham Group
SWIM
$824M
| $114K | ﹤0.01% |
17,674
-14,804
| -46% | -$99.6K |
|
2884
Perimeter Solutions
PRM
$5.02B
| $113K | ﹤0.01% |
+11,222
| New | +$126K |
|
|
NOTV
2885
DELISTED
Inotiv
NOTV
| $112K | ﹤0.01% |
50,684
-21,005
| -29% | -$77.1K |
|
2886
Cullinan Oncology
CGEM
$1.4B
| $112K | ﹤0.01% |
14,796
-27,409
| -65% | -$263K |
|
2887
PUT
Core Scientific
CORZ
$5.55B
| $110K | ﹤0.01% |
15,200
| – | – |
|
|
NOAH
2888
Noah Holdings
NOAH
$597M
| $110K | ﹤0.01% |
+11,629
| New | +$127K |
|
2889
BARK
BARK
$92.1M
| $109K | ﹤0.01% |
3,908
-3,040
| -44% | -$106K |
|
2890
Lightspeed Commerce
LSPD
$1.37B
| $106K | ﹤0.01% |
12,077
-352,323
| -97% | -$4.54M |
|
2891
Microbot Medical
MBOT
$99.4M
| $103K | ﹤0.01% |
+68,198
| New | +$121K |
|
|
AGIG
2892
Abundia Global Impact Group
AGIG
$43.3M
| $102K | ﹤0.01% |
13,278
+7,696
| +138% | +$101K |
|
|
IMA
2893
ImageneBio Inc
IMA
$63.8M
| $102K | ﹤0.01% |
6,619
-1,779
| -21% | -$30.7K |
|
2894
Flywire
FLYW
$2.36B
| $101K | ﹤0.01% |
+10,613
| New | +$167K |
|
2895
Vertical Aerospace
EVTL
$135M
| $101K | ﹤0.01% |
+29,990
| New | +$168K |
|
2896
Clarus
CLAR
$146M
| $101K | ﹤0.01% |
26,819
-23,750
| -47% | -$107K |
|
2897
Protara Therapeutics
TARA
$229M
| $100K | ﹤0.01% |
23,590
+9,957
| +73% | +$44.5K |
|
2898
CuriosityStream
CURI
$169M
| $100K | ﹤0.01% |
37,300
-1,197
| -3% | -$2.91K |
|
2899
Algoma Steel
ASTL
$424M
| $98.7K | ﹤0.01% |
18,213
-18,387
| -50% | -$138K |
|
2900
Harvard Bioscience
HBIO
$34.4M
| $98.1K | ﹤0.01% |
17,333
+13,751
| +384% | +$176K |
|
Similar funds
John Overdeck's Q1 2025 Portfolio in Review
As of Q1 2025, John Overdeck held 3,617 positions worth $46.8B, up 2% from $45.9B the previous quarter. Its ten largest holdings account for 8.1% of the portfolio.
John Overdeck deployed $2.08B of net new capital in Q1 2025, opening 458 new positions and adding to 1,225 existing holdings. Its largest new stake was Advanced Micro Devices: 2,246,952 shares worth $231M.
By sector, the portfolio is most concentrated in Technology at 18% of assets, up from 16% a quarter earlier, followed by Healthcare and Financials.
On the sell side, the largest reduction was Eli Lilly, an estimated $255M trimmed.
- John Overdeck's largest Q1 2025 buy was Advanced Micro Devices: 2,246,952 shares worth $231M.
- John Overdeck added most to State Street SPDR S&P 500 ETF Trust in Q1 2025, an estimated $510M increase.
- John Overdeck's biggest Q1 2025 reduction was Eli Lilly, cutting an estimated $255M.
- John Overdeck fully exited Coinbase in Q1 2025, selling an estimated $45M.
- John Overdeck's ten largest holdings make up 8.1% of its $46.8B portfolio in Q1 2025.
- John Overdeck opened 458 new positions and closed 452 in Q1 2025.
- John Overdeck's portfolio value rose 2% quarter-over-quarter to $46.8B.
Based on Two Sigma Investments's 13F filing for Q1 2025, filed 15 May 2025.