John Overdeck Two Sigma Investments
John Overdeck is a co-founder of Two Sigma Investments, one of the world’s leading quantitative and technology-driven investment firms. Two Sigma applies data science, machine learning, and large-scale computing to markets across asset classes. Overdeck’s firm is a central reference point in discussions of modern systematic investing.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$510M |
| 2 |
Broadcom
AVGO
|
+$318M |
| 3 |
Marvell Technology
MRVL
|
+$290M |
| 4 |
Salesforce
CRM
|
+$263M |
| 5 |
Advanced Micro Devices
AMD
|
+$250M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Eli Lilly
LLY
|
+$255M |
| 2 |
Progressive
PGR
|
+$244M |
| 3 |
Visa
V
|
+$238M |
| 4 |
Lam Research
LRCX
|
+$201M |
| 5 |
Elevance Health
ELV
|
+$190M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 17.88% |
| 2 | Healthcare | 13.28% |
| 3 | Financials | 10.32% |
| 4 | Industrials | 9.79% |
| 5 | Consumer Discretionary | 8.58% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
2826
OraSure Technologies
OSUR
$263M
| $164K | ﹤0.01% |
48,723
-104,306
| -68% | -$384K |
|
2827
American Battery Technology Co
ABAT
$327M
| $164K | ﹤0.01% |
159,411
+121,661
| +322% | +$165K |
|
2828
Sagimet Biosciences
SGMT
$635M
| $163K | ﹤0.01% |
49,849
-584
| -1% | -$2.45K |
|
|
ARDT
2829
Ardent Health
ARDT
$1.59B
| $162K | ﹤0.01% |
11,763
-13,078
| -53% | -$191K |
|
|
IGMS
2830
DELISTED
IGM Biosciences
IGMS
| $161K | ﹤0.01% |
139,770
+32,150
| +30% | +$59.8K |
|
2831
BlackSky Technology
BKSY
$1.05B
| $158K | ﹤0.01% |
20,487
-92,487
| -82% | -$1.16M |
|
2832
International Money Express
IMXI
$429M
| $158K | ﹤0.01% |
12,538
-25,315
| -67% | -$433K |
|
|
KZR
2833
DELISTED
Kezar Life Sciences
KZR
| $156K | ﹤0.01% |
31,870
-30,113
| -49% | -$183K |
|
2834
SIGA Technologies
SIGA
$211M
| $152K | ﹤0.01% |
+27,742
| New | +$164K |
|
|
BAND
2835
Bandwidth Inc
BAND
$1.49B
| $152K | ﹤0.01% |
11,577
-96,761
| -89% | -$1.58M |
|
2836
Southern California Bancorp
BCAL
$690M
| $149K | ﹤0.01% |
+10,393
| New | +$161K |
|
2837
AudioEye
AEYE
$91.9M
| $149K | ﹤0.01% |
13,391
-11,576
| -46% | -$175K |
|
|
WIMI
2838
WiMi Hologram Cloud
WIMI
$25.7M
| $148K | ﹤0.01% |
15,168
+12,721
| +520% | +$122K |
|
2839
Invivyd
IVVD
$278M
| $146K | ﹤0.01% |
240,607
-126,493
| -34% | -$113K |
|
2840
Cartesian Therapeutics
RNAC
$304M
| $145K | ﹤0.01% |
11,015
-797
| -7% | -$14.2K |
|
2841
Atomera
ATOM
$176M
| $144K | ﹤0.01% |
35,885
+19,803
| +123% | +$154K |
|
2842
Spire Global
SPIR
$563M
| $143K | ﹤0.01% |
17,701
-20,308
| -53% | -$269K |
|
2843
1-800-Flowers.com
FLWS
$249M
| $142K | ﹤0.01% |
24,084
+12,835
| +114% | +$94.4K |
|
2844
Telecom Argentina
TEO
$5.84B
| $142K | ﹤0.01% |
+13,896
| New | +$164K |
|
2845
Prelude Therapeutics
PRLD
$516M
| $141K | ﹤0.01% |
183,667
-48,172
| -21% | -$44.9K |
|
2846
Orion Group Holdings
ORN
$369M
| $139K | ﹤0.01% |
26,622
-778
| -3% | -$5.44K |
|
2847
KVH Industries
KVHI
$136M
| $138K | ﹤0.01% |
26,146
-10,989
| -30% | -$62.6K |
|
2848
Rush Street Interactive
RSI
$3.05B
| $138K | ﹤0.01% |
12,876
-44,199
| -77% | -$581K |
|
2849
Oramed Pharmaceuticals
ORMP
$200M
| $138K | ﹤0.01% |
64,418
-45,960
| -42% | -$106K |
|
2850
Sportsman's Warehouse
SPWH
$44.5M
| $136K | ﹤0.01% |
136,963
-131,212
| -49% | -$221K |
|
Similar funds
John Overdeck's Q1 2025 Portfolio in Review
As of Q1 2025, John Overdeck held 3,617 positions worth $46.8B, up 2% from $45.9B the previous quarter. Its ten largest holdings account for 8.1% of the portfolio.
John Overdeck deployed $2.08B of net new capital in Q1 2025, opening 458 new positions and adding to 1,225 existing holdings. Its largest new stake was Advanced Micro Devices: 2,246,952 shares worth $231M.
By sector, the portfolio is most concentrated in Technology at 18% of assets, up from 16% a quarter earlier, followed by Healthcare and Financials.
On the sell side, the largest reduction was Eli Lilly, an estimated $255M trimmed.
- John Overdeck's largest Q1 2025 buy was Advanced Micro Devices: 2,246,952 shares worth $231M.
- John Overdeck added most to State Street SPDR S&P 500 ETF Trust in Q1 2025, an estimated $510M increase.
- John Overdeck's biggest Q1 2025 reduction was Eli Lilly, cutting an estimated $255M.
- John Overdeck fully exited Coinbase in Q1 2025, selling an estimated $45M.
- John Overdeck's ten largest holdings make up 8.1% of its $46.8B portfolio in Q1 2025.
- John Overdeck opened 458 new positions and closed 452 in Q1 2025.
- John Overdeck's portfolio value rose 2% quarter-over-quarter to $46.8B.
Based on Two Sigma Investments's 13F filing for Q1 2025, filed 15 May 2025.