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APM

Avidity Partners Management Portfolio holdings

AUM $936M
1-Year Est. Return 195%
This Fund
S&P 500
This Quarter Est. Return
+48.19%
1 Year Est. Return
+195%
3 Year Est. Return
+460.87%
5 Year Est. Return
+815.5%
10 Year Est. Return
–
AUM
$439M
AUM Growth
-$62.6M
Cap. Flow
-$159M
Cap. Flow %
-36.16%
Top 10 Hldgs %
66.42%
Holding
69
New
13
Increased
8
Reduced
20
Closed
26

Top Buys

Rank Stock Value
1
DNTH icon
Dianthus Therapeutics
DNTH
+$37.3M
2
MDT icon
Medtronic
MDT
+$17.5M
3
BMY icon
Bristol-Myers Squibb
BMY
+$12M
4
PFE icon
Pfizer
PFE
+$9.04M
5
KVUE icon
Kenvue
KVUE
+$5.41M

Top Sells

Rank Stock Value
1
NTRA icon
Natera
NTRA
+$20.4M
2
THC icon
Tenet Healthcare
THC
+$18.7M
3
DXCM icon
DexCom
DXCM
+$18.4M
4
HNGE
Hinge Health
HNGE
+$16.7M
5
BSX icon
Boston Scientific
BSX
+$16.3M

Sector Composition

Rank Sector Weight
1 Healthcare 99.02%
2 Consumer Staples 0.98%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
HUM icon
51
Humana
HUM
$46.7B
– –
-27,600
Closed -$6.75M
ISRG icon
52
Intuitive Surgical
ISRG
$130B
– –
-27,100
Closed -$14.7M
KZR
53
DELISTED
Kezar Life Sciences
KZR
– –
-502,600
Closed -$2.3M
MDGL icon
54
Madrigal Pharmaceuticals
MDGL
$12.4B
– –
-19,000
Closed -$5.75M
MLTX icon
55
MoonLake Immunotherapeutics
MLTX
$1.59B
– –
-39,000
Closed -$1.84M
NTLA icon
56
Intellia Therapeutics
NTLA
$1.52B
– –
-232,000
Closed -$2.18M
OGN icon
57
Organon & Co
OGN
$3.55B
– –
-640,000
Closed -$6.2M
QURE icon
58
uniQure
QURE
$2.52B
– –
-207,000
Closed -$2.89M
RARE icon
59
Ultragenyx Pharmaceutical
RARE
$2.56B
– –
-154,000
Closed -$5.6M
RVMD icon
60
Revolution Medicines
RVMD
$39.1B
– –
-228,600
Closed -$8.41M
RVPH
61
DELISTED
REVIVA PHARMA HLDGS INC
RVPH
– –
-6,900
Closed -$52.6K
SLNO
62
DELISTED
Soleno Therapeutics
SLNO
– –
-32,000
Closed -$2.68M
SNDX icon
63
CALL
Syndax Pharmaceuticals
SNDX
$1.74B
– –
-340,000
Closed -$3.18M
SNDX icon
64
Syndax Pharmaceuticals
SNDX
$1.74B
– –
-150,000
Closed -$1.4M
SPRY icon
65
ARS Pharmaceuticals
SPRY
$563M
– –
-140,000
Closed -$2.44M
THC icon
66
Tenet Healthcare
THC
$22.6B
– –
-106,000
Closed -$18.7M
VRNA
67
DELISTED
Verona Pharma
VRNA
– –
-33,800
Closed -$3.2M
HNGE
68
Hinge Health
HNGE
$5.82B
– –
-322,344
Closed -$16.7M
OMDA
69
Omada Health Inc
OMDA
$1.21B
– –
-390,600
Closed -$7.15M
1 2
3

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Avidity Partners Management's Q3 2025 Portfolio in Review

As of Q3 2025, Avidity Partners Management held 69 positions worth $439M, down 12% from $502M the previous quarter. Its ten largest holdings account for 66% of the portfolio.

Avidity Partners Management withdrew a net $159M in Q3 2025, closing 26 positions and reducing 20 holdings. Its most notable exit was Tenet Healthcare, an estimated $18.7M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, down from 99% a quarter earlier, followed by Consumer Staples.

Against the trend, Avidity Partners Management opened a new position in Medtronic worth $18.2M.

  • Avidity Partners Management's largest Q3 2025 buy was Medtronic: 190,600 shares worth $18.2M.
  • Avidity Partners Management added most to Dianthus Therapeutics in Q3 2025, an estimated $37.3M increase.
  • Avidity Partners Management's biggest Q3 2025 reduction was Natera, cutting an estimated $20.4M.
  • Avidity Partners Management fully exited Tenet Healthcare in Q3 2025, selling an estimated $18.7M.
  • Avidity Partners Management's ten largest holdings make up 66% of its $439M portfolio in Q3 2025.
  • Avidity Partners Management opened 13 new positions and closed 26 in Q3 2025.
  • Avidity Partners Management's portfolio value fell 12% quarter-over-quarter to $439M.

Based on Avidity Partners Management's 13F filing for Q3 2025, filed 14 Nov 2025.